Associations Between the Macular Microvasculatures and Subclinical Atherosclerosis in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study
ObjectiveTo investigate the associations between the macular microvasculature assessed by optical coherence tomography angiography (OCTA) and subclinical atherosclerosis in patients with type 2 diabetes.MethodsWe included patients with type 2 diabetes who received comprehensive medical and ophthalmi...
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| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.843176/full |
| _version_ | 1819282046433886208 |
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| author | Jooyoung Yoon Hyo Joo Kang Joo Yong Lee Joo Yong Lee June-Gone Kim June-Gone Kim Young Hee Yoon Young Hee Yoon Chang Hee Jung Chang Hee Jung Yoon Jeon Kim Yoon Jeon Kim |
| author_facet | Jooyoung Yoon Hyo Joo Kang Joo Yong Lee Joo Yong Lee June-Gone Kim June-Gone Kim Young Hee Yoon Young Hee Yoon Chang Hee Jung Chang Hee Jung Yoon Jeon Kim Yoon Jeon Kim |
| author_sort | Jooyoung Yoon |
| collection | DOAJ |
| description | ObjectiveTo investigate the associations between the macular microvasculature assessed by optical coherence tomography angiography (OCTA) and subclinical atherosclerosis in patients with type 2 diabetes.MethodsWe included patients with type 2 diabetes who received comprehensive medical and ophthalmic evaluations, such as carotid ultrasonography and OCTA at a hospital-based diabetic clinic in a consecutive manner. Among them, 254 eyes with neither diabetic macular edema (DME) nor history of ophthalmic treatment from 254 patients were included. The presence of increased carotid intima-media thickness (IMT) (>1.0 mm) or carotid plaque was defined as subclinical atherosclerosis. OCTA characteristics focused on foveal avascular zone (FAZ) related parameters and parafoveal vessel density (VD) were compared in terms of subclinical atherosclerosis, and risk factors for subclinical atherosclerosis were identified using a multivariate logistic regression analysis.ResultsSubclinical atherosclerosis was observed in 148 patients (58.3%). The subclinical atherosclerosis group were older (p < 0.001), had a greater portion of patients who were men (p = 0.001) and who had hypertension (p = 0.042), had longer diabetes duration (p = 0.014), and lower VD around FAZ (p = 0.010), and parafoveal VD (all p < 0.05). In the multivariate logistic regression analysis, older age (p ≤ 0.001), male sex (p ≤ 0.001), lower VD around FAZ (p = 0.043), lower parafoveal VD of both superficial capillary plexus (SCP) (p = 0.011), and deep capillary plexus (DCP) (p = 0.046) were significant factors for subclinical atherosclerosis.ConclusionThe decrease in VD around FAZ, and the VD loss in parafoveal area of both SCP and DCP were significantly associated with subclinical atherosclerosis in patients with type 2 diabetes, suggesting that common pathogenic mechanisms might predispose to diabetic micro- and macrovascular complications. |
| first_indexed | 2024-12-24T01:09:21Z |
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| id | doaj.art-24f36e584b084903ac4d4d5ad14a867e |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-24T01:09:21Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-24f36e584b084903ac4d4d5ad14a867e2022-12-21T17:23:04ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-03-01910.3389/fmed.2022.843176843176Associations Between the Macular Microvasculatures and Subclinical Atherosclerosis in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography StudyJooyoung Yoon0Hyo Joo Kang1Joo Yong Lee2Joo Yong Lee3June-Gone Kim4June-Gone Kim5Young Hee Yoon6Young Hee Yoon7Chang Hee Jung8Chang Hee Jung9Yoon Jeon Kim10Yoon Jeon Kim11Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaDepartment of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South KoreaDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaObjectiveTo investigate the associations between the macular microvasculature assessed by optical coherence tomography angiography (OCTA) and subclinical atherosclerosis in patients with type 2 diabetes.MethodsWe included patients with type 2 diabetes who received comprehensive medical and ophthalmic evaluations, such as carotid ultrasonography and OCTA at a hospital-based diabetic clinic in a consecutive manner. Among them, 254 eyes with neither diabetic macular edema (DME) nor history of ophthalmic treatment from 254 patients were included. The presence of increased carotid intima-media thickness (IMT) (>1.0 mm) or carotid plaque was defined as subclinical atherosclerosis. OCTA characteristics focused on foveal avascular zone (FAZ) related parameters and parafoveal vessel density (VD) were compared in terms of subclinical atherosclerosis, and risk factors for subclinical atherosclerosis were identified using a multivariate logistic regression analysis.ResultsSubclinical atherosclerosis was observed in 148 patients (58.3%). The subclinical atherosclerosis group were older (p < 0.001), had a greater portion of patients who were men (p = 0.001) and who had hypertension (p = 0.042), had longer diabetes duration (p = 0.014), and lower VD around FAZ (p = 0.010), and parafoveal VD (all p < 0.05). In the multivariate logistic regression analysis, older age (p ≤ 0.001), male sex (p ≤ 0.001), lower VD around FAZ (p = 0.043), lower parafoveal VD of both superficial capillary plexus (SCP) (p = 0.011), and deep capillary plexus (DCP) (p = 0.046) were significant factors for subclinical atherosclerosis.ConclusionThe decrease in VD around FAZ, and the VD loss in parafoveal area of both SCP and DCP were significantly associated with subclinical atherosclerosis in patients with type 2 diabetes, suggesting that common pathogenic mechanisms might predispose to diabetic micro- and macrovascular complications.https://www.frontiersin.org/articles/10.3389/fmed.2022.843176/fullcarotid ultrasonographyoptical coherence tomography angiography (OCTA)retinal microvasculaturessubclinical atherosclerosistype 2 diabetes |
| spellingShingle | Jooyoung Yoon Hyo Joo Kang Joo Yong Lee Joo Yong Lee June-Gone Kim June-Gone Kim Young Hee Yoon Young Hee Yoon Chang Hee Jung Chang Hee Jung Yoon Jeon Kim Yoon Jeon Kim Associations Between the Macular Microvasculatures and Subclinical Atherosclerosis in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study Frontiers in Medicine carotid ultrasonography optical coherence tomography angiography (OCTA) retinal microvasculatures subclinical atherosclerosis type 2 diabetes |
| title | Associations Between the Macular Microvasculatures and Subclinical Atherosclerosis in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study |
| title_full | Associations Between the Macular Microvasculatures and Subclinical Atherosclerosis in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study |
| title_fullStr | Associations Between the Macular Microvasculatures and Subclinical Atherosclerosis in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study |
| title_full_unstemmed | Associations Between the Macular Microvasculatures and Subclinical Atherosclerosis in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study |
| title_short | Associations Between the Macular Microvasculatures and Subclinical Atherosclerosis in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study |
| title_sort | associations between the macular microvasculatures and subclinical atherosclerosis in patients with type 2 diabetes an optical coherence tomography angiography study |
| topic | carotid ultrasonography optical coherence tomography angiography (OCTA) retinal microvasculatures subclinical atherosclerosis type 2 diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.843176/full |
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