Nontuberculous mycobacteria pathogenesis and biofilm assembly
Nontuberculous mycobacteria (NTM) are emergent pathogens whose importance in human health has been gaining relevance after being recognized as etiological agents of opportunist infections in HIV patients. Currently, NTM are recognized as etiological agents of several respiratory and extra-respirator...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | International Journal of Mycobacteriology |
| Subjects: | |
| Online Access: | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=1;spage=36;epage=43;aulast=Sousa |
| _version_ | 1818144374736814080 |
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| author | Sara Sousa Maria Bandeira Patricia Almeida Carvalho Aida Duarte Luisa Jordao |
| author_facet | Sara Sousa Maria Bandeira Patricia Almeida Carvalho Aida Duarte Luisa Jordao |
| author_sort | Sara Sousa |
| collection | DOAJ |
| description | Nontuberculous mycobacteria (NTM) are emergent pathogens whose importance in human health has been gaining relevance after being recognized as etiological agents of opportunist infections in HIV patients. Currently, NTM are recognized as etiological agents of several respiratory and extra-respiratory infections of immune-competent individuals. The environmental nature of NTM together with the ability to assemble biofilms on different surfaces plays a key role on their pathogenesis.
In the present work the ability of three fast-growing NTM (Mycobacterium smegmatis, Mycobacterium fortuitum and Mycobacterium chelonae) to persist within a model of human alveolar macrophages was evaluated. Most often human infections with NTM occur by contact with the environment. Biofilms can work as environmental reservoirs. For this reason, it was decided to evaluate the ability of NTM to assemble biofilms on different surfaces. Scanning electron microscopy was used to elucidate the biofilm structure. The ability to assemble biofilms was connected with the ability to spread on solid media known as sliding. Biofilm assembly and intracellular persistence seems to be ruled by different mechanisms. |
| first_indexed | 2024-12-11T11:46:33Z |
| format | Article |
| id | doaj.art-24f6c239cb374516bbd657e5bb8f3d20 |
| institution | Directory Open Access Journal |
| issn | 2212-5531 2212-554X |
| language | English |
| last_indexed | 2024-12-11T11:46:33Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj.art-24f6c239cb374516bbd657e5bb8f3d202022-12-22T01:08:27ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2015-01-0141364310.1016/j.ijmyco.2014.11.065Nontuberculous mycobacteria pathogenesis and biofilm assemblySara SousaMaria BandeiraPatricia Almeida CarvalhoAida DuarteLuisa JordaoNontuberculous mycobacteria (NTM) are emergent pathogens whose importance in human health has been gaining relevance after being recognized as etiological agents of opportunist infections in HIV patients. Currently, NTM are recognized as etiological agents of several respiratory and extra-respiratory infections of immune-competent individuals. The environmental nature of NTM together with the ability to assemble biofilms on different surfaces plays a key role on their pathogenesis. In the present work the ability of three fast-growing NTM (Mycobacterium smegmatis, Mycobacterium fortuitum and Mycobacterium chelonae) to persist within a model of human alveolar macrophages was evaluated. Most often human infections with NTM occur by contact with the environment. Biofilms can work as environmental reservoirs. For this reason, it was decided to evaluate the ability of NTM to assemble biofilms on different surfaces. Scanning electron microscopy was used to elucidate the biofilm structure. The ability to assemble biofilms was connected with the ability to spread on solid media known as sliding. Biofilm assembly and intracellular persistence seems to be ruled by different mechanisms.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=1;spage=36;epage=43;aulast=SousaNontuberculous mycobacteria (NTM)BiofilmsScanning electron microscopy (SEM)Host–pathogen interaction |
| spellingShingle | Sara Sousa Maria Bandeira Patricia Almeida Carvalho Aida Duarte Luisa Jordao Nontuberculous mycobacteria pathogenesis and biofilm assembly International Journal of Mycobacteriology Nontuberculous mycobacteria (NTM) Biofilms Scanning electron microscopy (SEM) Host–pathogen interaction |
| title | Nontuberculous mycobacteria pathogenesis and biofilm assembly |
| title_full | Nontuberculous mycobacteria pathogenesis and biofilm assembly |
| title_fullStr | Nontuberculous mycobacteria pathogenesis and biofilm assembly |
| title_full_unstemmed | Nontuberculous mycobacteria pathogenesis and biofilm assembly |
| title_short | Nontuberculous mycobacteria pathogenesis and biofilm assembly |
| title_sort | nontuberculous mycobacteria pathogenesis and biofilm assembly |
| topic | Nontuberculous mycobacteria (NTM) Biofilms Scanning electron microscopy (SEM) Host–pathogen interaction |
| url | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=1;spage=36;epage=43;aulast=Sousa |
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