A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractions
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
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| Series: | HeartRhythm Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214027121002062 |
| _version_ | 1818744016066314240 |
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| author | Xiaozhi Gao, BS Dan Ye, MD Wei Zhou, MD David J. Tester, BS Michael J. Ackerman, MD, PhD John R. Giudicessi, MD, PhD |
| author_facet | Xiaozhi Gao, BS Dan Ye, MD Wei Zhou, MD David J. Tester, BS Michael J. Ackerman, MD, PhD John R. Giudicessi, MD, PhD |
| author_sort | Xiaozhi Gao, BS |
| collection | DOAJ |
| first_indexed | 2024-12-18T02:37:36Z |
| format | Article |
| id | doaj.art-24f75c8fdb654c1899571213150bd812 |
| institution | Directory Open Access Journal |
| issn | 2214-0271 |
| language | English |
| last_indexed | 2024-12-18T02:37:36Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | HeartRhythm Case Reports |
| spelling | doaj.art-24f75c8fdb654c1899571213150bd8122022-12-21T21:23:45ZengElsevierHeartRhythm Case Reports2214-02712022-01-01815459A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractionsXiaozhi Gao, BS0Dan Ye, MD1Wei Zhou, MD2David J. Tester, BS3Michael J. Ackerman, MD, PhD4John R. Giudicessi, MD, PhD5Departments of Cardiovascular Medicine (Division of Heart Rhythm Services), Pediatric and Adolescent Medicine (Division of Pediatric Cardiology and the Windland Smith Rice Genetic Heart Rhythm Clinic), and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, MinnesotaDepartments of Cardiovascular Medicine (Division of Heart Rhythm Services), Pediatric and Adolescent Medicine (Division of Pediatric Cardiology and the Windland Smith Rice Genetic Heart Rhythm Clinic), and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, MinnesotaDepartments of Cardiovascular Medicine (Division of Heart Rhythm Services), Pediatric and Adolescent Medicine (Division of Pediatric Cardiology and the Windland Smith Rice Genetic Heart Rhythm Clinic), and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, MinnesotaDepartments of Cardiovascular Medicine (Division of Heart Rhythm Services), Pediatric and Adolescent Medicine (Division of Pediatric Cardiology and the Windland Smith Rice Genetic Heart Rhythm Clinic), and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, MinnesotaDepartments of Cardiovascular Medicine (Division of Heart Rhythm Services), Pediatric and Adolescent Medicine (Division of Pediatric Cardiology and the Windland Smith Rice Genetic Heart Rhythm Clinic), and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, MinnesotaDepartments of Cardiovascular Medicine (Division of Heart Rhythm Services), Pediatric and Adolescent Medicine (Division of Pediatric Cardiology and the Windland Smith Rice Genetic Heart Rhythm Clinic), and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Medicine (Division of Circulatory Failure), Mayo Clinic, Rochester, Minnesota; Address reprint requests and correspondence: Dr John R. Giudicessi, Department of Cardiovascular Medicine (Divisions of Heart Rhythm Services and Circulatory Failure), Mayo Clinic, Rochester, MN 55905.http://www.sciencedirect.com/science/article/pii/S2214027121002062ChannelopathiesFlecainideMEPPCSCN5ASudden cardiac death |
| spellingShingle | Xiaozhi Gao, BS Dan Ye, MD Wei Zhou, MD David J. Tester, BS Michael J. Ackerman, MD, PhD John R. Giudicessi, MD, PhD A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractions HeartRhythm Case Reports Channelopathies Flecainide MEPPC SCN5A Sudden cardiac death |
| title | A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractions |
| title_full | A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractions |
| title_fullStr | A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractions |
| title_full_unstemmed | A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractions |
| title_short | A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractions |
| title_sort | novel functional variant residing outside the scn5a encoded nav1 5 voltage sensing domain causes multifocal ectopic purkinje related premature contractions |
| topic | Channelopathies Flecainide MEPPC SCN5A Sudden cardiac death |
| url | http://www.sciencedirect.com/science/article/pii/S2214027121002062 |
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