Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis
Dengue virus (DENV) and parvovirus B19 (B19V) infections are acute exanthematic febrile illnesses that are not easily differentiated on clinical grounds and affect the paediatric population. Patients with these acute exanthematic diseases were studied. Fever was more frequent in DENV than in B19V-in...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2012-02-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000100007&lng=en&tlng=en |
| _version_ | 1797703164492775424 |
|---|---|
| author | Luzia Maria de-Oliveira-Pinto Mariana Gandini Laís Picinini Freitas Marilda Mendonça Siqueira Cíntia Ferreira Marinho Sérgio Setúbal Claire Fernandes Kubelka Oswaldo Gonçalves Cruz Solange Artimos de Oliveira |
| author_facet | Luzia Maria de-Oliveira-Pinto Mariana Gandini Laís Picinini Freitas Marilda Mendonça Siqueira Cíntia Ferreira Marinho Sérgio Setúbal Claire Fernandes Kubelka Oswaldo Gonçalves Cruz Solange Artimos de Oliveira |
| author_sort | Luzia Maria de-Oliveira-Pinto |
| collection | DOAJ |
| description | Dengue virus (DENV) and parvovirus B19 (B19V) infections are acute exanthematic febrile illnesses that are not easily differentiated on clinical grounds and affect the paediatric population. Patients with these acute exanthematic diseases were studied. Fever was more frequent in DENV than in B19V-infected patients. Arthritis/arthralgias with DENV infection were shown to be significantly more frequent in adults than in children. The circulating levels of interleukin (IL)-1 receptor antagonist (Ra), CXCL10/inducible protein-10 (IP-10), CCL4/macrophage inflammatory protein-1 beta and CCL2/monocyte chemotactic protein-1 (MCP-1) were determined by multiplex immunoassay in serum samples obtained from B19V (37) and DENV-infected (36) patients and from healthy individuals (7). Forward stepwise logistic regression analysis revealed that circulating CXCL10/IP-10 tends to be associated with DENV infection and that IL-1Ra was significantly associated with DENV infection. Similar analysis showed that circulating CCL2/MCP-1 tends to be associated with B19V infection. In dengue fever, increased circulating IL-1Ra may exert antipyretic actions in an effort to counteract the already increased concentrations of IL-1β, while CXCL10/IP-10 was confirmed as a strong pro-inflammatory marker. Recruitment of monocytes/macrophages and upregulation of the humoral immune response by CCL2/MCP-1 by B19V may be involved in the persistence of the infection. Children with B19V or DENV infections had levels of these cytokines similar to those of adult patients. |
| first_indexed | 2024-03-12T05:00:35Z |
| format | Article |
| id | doaj.art-24f7900f01fa400aaa6b11023f811d10 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:00:35Z |
| publishDate | 2012-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-24f7900f01fa400aaa6b11023f811d102023-09-03T09:11:55ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602012-02-011071485610.1590/S0074-02762012000100007S0074-02762012000100007Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosisLuzia Maria de-Oliveira-Pinto0Mariana Gandini1Laís Picinini Freitas2Marilda Mendonça Siqueira3Cíntia Ferreira Marinho4Sérgio Setúbal5Claire Fernandes Kubelka6Oswaldo Gonçalves Cruz7Solange Artimos de Oliveira8Fundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzUniversidade Federal FluminenseFundação Oswaldo CruzFundação Oswaldo CruzUniversidade Federal FluminenseDengue virus (DENV) and parvovirus B19 (B19V) infections are acute exanthematic febrile illnesses that are not easily differentiated on clinical grounds and affect the paediatric population. Patients with these acute exanthematic diseases were studied. Fever was more frequent in DENV than in B19V-infected patients. Arthritis/arthralgias with DENV infection were shown to be significantly more frequent in adults than in children. The circulating levels of interleukin (IL)-1 receptor antagonist (Ra), CXCL10/inducible protein-10 (IP-10), CCL4/macrophage inflammatory protein-1 beta and CCL2/monocyte chemotactic protein-1 (MCP-1) were determined by multiplex immunoassay in serum samples obtained from B19V (37) and DENV-infected (36) patients and from healthy individuals (7). Forward stepwise logistic regression analysis revealed that circulating CXCL10/IP-10 tends to be associated with DENV infection and that IL-1Ra was significantly associated with DENV infection. Similar analysis showed that circulating CCL2/MCP-1 tends to be associated with B19V infection. In dengue fever, increased circulating IL-1Ra may exert antipyretic actions in an effort to counteract the already increased concentrations of IL-1β, while CXCL10/IP-10 was confirmed as a strong pro-inflammatory marker. Recruitment of monocytes/macrophages and upregulation of the humoral immune response by CCL2/MCP-1 by B19V may be involved in the persistence of the infection. Children with B19V or DENV infections had levels of these cytokines similar to those of adult patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000100007&lng=en&tlng=endengueparvovirus B19chemokinesIL-1Ra |
| spellingShingle | Luzia Maria de-Oliveira-Pinto Mariana Gandini Laís Picinini Freitas Marilda Mendonça Siqueira Cíntia Ferreira Marinho Sérgio Setúbal Claire Fernandes Kubelka Oswaldo Gonçalves Cruz Solange Artimos de Oliveira Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis Memorias do Instituto Oswaldo Cruz dengue parvovirus B19 chemokines IL-1Ra |
| title | Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_full | Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_fullStr | Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_full_unstemmed | Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_short | Profile of circulating levels of IL-1Ra, CXCL10/IP-10, CCL4/MIP-1β and CCL2/MCP-1 in dengue fever and parvovirosis |
| title_sort | profile of circulating levels of il 1ra cxcl10 ip 10 ccl4 mip 1β and ccl2 mcp 1 in dengue fever and parvovirosis |
| topic | dengue parvovirus B19 chemokines IL-1Ra |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000100007&lng=en&tlng=en |
| work_keys_str_mv | AT luziamariadeoliveirapinto profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis AT marianagandini profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis AT laispicininifreitas profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis AT marildamendoncasiqueira profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis AT cintiaferreiramarinho profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis AT sergiosetubal profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis AT clairefernandeskubelka profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis AT oswaldogoncalvescruz profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis AT solangeartimosdeoliveira profileofcirculatinglevelsofil1racxcl10ip10ccl4mip1bandccl2mcp1indenguefeverandparvovirosis |