The hypoxia-inducible factor-1α in stemness and resistance to chemotherapy in gastric cancer: Future directions for therapeutic targeting

The hypoxia-inducible factor-1α in stemness and resistance to chemotherapy in gastric cancer: Future directions for therapeutic targeting

Hypoxia-inducible factor-1α (HIF-1α) is a crucial mediator of intra-tumoral heterogeneity, tumor progression, and unresponsiveness to therapy in tumors with hypoxia. Gastric tumors, one of the most aggressive tumors in the clinic, are highly enriched in hypoxic niches, and the degree of hypoxia is s...

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Bibliographic Details
Main Author:	Gulnihal Ozcan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	hypoxia-inducible factor-1α gastric cancer stemness chemoresistance deregulated signaling
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1082057/full

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