Gene-environment and gene-gene interactions between CHRNA3 rs1051730, XRCC1 rs25487, and ERCC1 rs735482 variants highly elevate the risk of lung cancer

Gene-environment and gene-gene interactions between CHRNA3 rs1051730, XRCC1 rs25487, and ERCC1 rs735482 variants highly elevate the risk of lung cancer

Abstract Background Gene-gene and gene-environment interactions play an important role in cancer susceptibility. In this work, we studied the association of XRCC1 rs25487, ERCC1 rs735482, and CHRNA3 rs1051730 variants with lung cancer and assessed the modulatory effect of potential interaction betwe...

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Bibliographic Details
Main Authors: Nada Ezzeldin, Dalia El-Lebedy, Asmaa Mohammed
Format: Article
Language:English
Published: SpringerOpen 2019-11-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Lung cancer
Smoking
XRCC1
ERCC1
CHRNA3
Polymorphism
Online Access:http://link.springer.com/article/10.1186/s43042-019-0034-1

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