Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review
Abstract Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) represents the initial tumor suppressor gene identified to possess phosphatase activity, governing various cellular processes including cell cycle regulation, migration, metabolic pathways, autophagy, oxidative stress response,...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-04-01
|
| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-024-06657-y |
| _version_ | 1797199108907204608 |
|---|---|
| author | Yue Li Ruishuang Ma Xia Hao |
| author_facet | Yue Li Ruishuang Ma Xia Hao |
| author_sort | Yue Li |
| collection | DOAJ |
| description | Abstract Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) represents the initial tumor suppressor gene identified to possess phosphatase activity, governing various cellular processes including cell cycle regulation, migration, metabolic pathways, autophagy, oxidative stress response, and cellular senescence. Current evidence suggests that PTEN is critical for stem cell maintenance, self-renewal, migration, lineage commitment, and differentiation. Based on the latest available evidence, we provide a comprehensive overview of the mechanisms by which PTEN regulates activities of different stem cell populations and influences neurological disorders, encompassing autism, stroke, spinal cord injury, traumatic brain injury, Alzheimer’s disease and Parkinson’s disease. This review aims to elucidate the therapeutic impacts and mechanisms of PTEN in relation to neurogenesis or the stem cell niche across a range of neurological disorders, offering a foundation for innovative therapeutic approaches aimed at tissue repair and regeneration in neurological disorders. This review unravels novel therapeutic strategies for tissue restoration and regeneration in neurological disorders based on the regulatory mechanisms of PTEN on neurogenesis and the stem cell niche. |
| first_indexed | 2024-04-24T07:10:31Z |
| format | Article |
| id | doaj.art-24faaf11bb0f4aefbbe8c87118176482 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-24T07:10:31Z |
| publishDate | 2024-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-24faaf11bb0f4aefbbe8c871181764822024-04-21T11:31:54ZengNature Publishing GroupCell Death and Disease2041-48892024-04-0115411310.1038/s41419-024-06657-yTherapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth reviewYue Li0Ruishuang Ma1Xia Hao2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauState Key Laboratory of Component-Based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineState Key Laboratory of Component-Based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese MedicineAbstract Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) represents the initial tumor suppressor gene identified to possess phosphatase activity, governing various cellular processes including cell cycle regulation, migration, metabolic pathways, autophagy, oxidative stress response, and cellular senescence. Current evidence suggests that PTEN is critical for stem cell maintenance, self-renewal, migration, lineage commitment, and differentiation. Based on the latest available evidence, we provide a comprehensive overview of the mechanisms by which PTEN regulates activities of different stem cell populations and influences neurological disorders, encompassing autism, stroke, spinal cord injury, traumatic brain injury, Alzheimer’s disease and Parkinson’s disease. This review aims to elucidate the therapeutic impacts and mechanisms of PTEN in relation to neurogenesis or the stem cell niche across a range of neurological disorders, offering a foundation for innovative therapeutic approaches aimed at tissue repair and regeneration in neurological disorders. This review unravels novel therapeutic strategies for tissue restoration and regeneration in neurological disorders based on the regulatory mechanisms of PTEN on neurogenesis and the stem cell niche.https://doi.org/10.1038/s41419-024-06657-y |
| spellingShingle | Yue Li Ruishuang Ma Xia Hao Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review Cell Death and Disease |
| title | Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review |
| title_full | Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review |
| title_fullStr | Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review |
| title_full_unstemmed | Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review |
| title_short | Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review |
| title_sort | therapeutic role of pten in tissue regeneration for management of neurological disorders stem cell behaviors to an in depth review |
| url | https://doi.org/10.1038/s41419-024-06657-y |
| work_keys_str_mv | AT yueli therapeuticroleofptenintissueregenerationformanagementofneurologicaldisordersstemcellbehaviorstoanindepthreview AT ruishuangma therapeuticroleofptenintissueregenerationformanagementofneurologicaldisordersstemcellbehaviorstoanindepthreview AT xiahao therapeuticroleofptenintissueregenerationformanagementofneurologicaldisordersstemcellbehaviorstoanindepthreview |