The Neurokinin-1 Receptor Contributes to the Early Phase of Lipopolysaccharide-Induced Fever via Stimulation of Peripheral Cyclooxygenase-2 Protein Expression in Mice

The Neurokinin-1 Receptor Contributes to the Early Phase of Lipopolysaccharide-Induced Fever via Stimulation of Peripheral Cyclooxygenase-2 Protein Expression in Mice

Neurokinin (NK) signaling is involved in various inflammatory processes. A common manifestation of systemic inflammation is fever, which is usually induced in animal models with the administration of bacterial lipopolysaccharide (LPS). A role for the NK1 receptor was shown in LPS-induced fever, but...

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Bibliographic Details
Main Authors: Eszter Pakai, Valeria Tekus, Csaba Zsiboras, Zoltan Rumbus, Emoke Olah, Patrik Keringer, Nora Khidhir, Robert Matics, Laszlo Deres, Katalin Ordog, Nikolett Szentes, Krisztina Pohoczky, Agnes Kemeny, Peter Hegyi, Erika Pinter, Andras Garami
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
fever
thermoregulation
systemic inflammation
endotoxin
cyclooxygenase
autonomic thermoeffectors
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00166/full

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