Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling

Iron oxide nanoparticles (IONPs) are extensively used in bone-related studies as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, IONPs enter the cell where they promote osteogenic differentiation and inhibit osteoclastogenesis. Static magnetic fie...

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Bibliografiske detaljer
Main Authors: Jiancheng Yang, Jiawen Wu, Zengfeng Guo, Gejing Zhang, Hao Zhang
Format: Article
Sprog:English
Udgivet: MDPI AG 2022-10-01
Serier:Cells
Fag:
static magnetic fields
iron oxide nanoparticles
bone remodeling
osteoblast
osteoclast
bone regeneration
Online adgang:https://www.mdpi.com/2073-4409/11/20/3298
Beskrivelse
Summary:Iron oxide nanoparticles (IONPs) are extensively used in bone-related studies as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, IONPs enter the cell where they promote osteogenic differentiation and inhibit osteoclastogenesis. Static magnetic fields (SMFs) were also found to enhance osteoblast differentiation and hinder osteoclastic differentiation. Once IONPs are exposed to an SMF, they become rapidly magnetized. IONPs and SMFs work together to synergistically enhance the effectiveness of their individual effects on the differentiation and function of osteoblasts and osteoclasts. This article reviewed the individual and combined effects of different types of IONPs and different intensities of SMFs on bone remodeling. We also discussed the mechanism underlying the synergistic effects of IONPs and SMFs on bone remodeling.
ISSN:2073-4409

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