Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling
Iron oxide nanoparticles (IONPs) are extensively used in bone-related studies as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, IONPs enter the cell where they promote osteogenic differentiation and inhibit osteoclastogenesis. Static magnetic fie...
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
MDPI AG
2022-10-01
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| Colección: | Cells |
| Materias: | |
| Acceso en línea: | https://www.mdpi.com/2073-4409/11/20/3298 |
| _version_ | 1827651010023129088 |
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| author | Jiancheng Yang Jiawen Wu Zengfeng Guo Gejing Zhang Hao Zhang |
| author_facet | Jiancheng Yang Jiawen Wu Zengfeng Guo Gejing Zhang Hao Zhang |
| author_sort | Jiancheng Yang |
| collection | DOAJ |
| description | Iron oxide nanoparticles (IONPs) are extensively used in bone-related studies as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, IONPs enter the cell where they promote osteogenic differentiation and inhibit osteoclastogenesis. Static magnetic fields (SMFs) were also found to enhance osteoblast differentiation and hinder osteoclastic differentiation. Once IONPs are exposed to an SMF, they become rapidly magnetized. IONPs and SMFs work together to synergistically enhance the effectiveness of their individual effects on the differentiation and function of osteoblasts and osteoclasts. This article reviewed the individual and combined effects of different types of IONPs and different intensities of SMFs on bone remodeling. We also discussed the mechanism underlying the synergistic effects of IONPs and SMFs on bone remodeling. |
| first_indexed | 2024-03-09T20:28:52Z |
| format | Article |
| id | doaj.art-24fbe28d475848f68ae5310f26b51a9e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:28:52Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-24fbe28d475848f68ae5310f26b51a9e2023-11-23T23:28:48ZengMDPI AGCells2073-44092022-10-011120329810.3390/cells11203298Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone RemodelingJiancheng Yang0Jiawen Wu1Zengfeng Guo2Gejing Zhang3Hao Zhang4Department of Spine Surgery, People’s Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen 518109, ChinaDepartment of Spine Surgery, People’s Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen 518109, ChinaDepartment of Spine Surgery, People’s Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen 518109, ChinaKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaDepartment of Spine Surgery, People’s Hospital of Longhua, Affiliated Hospital of Southern Medical University, Shenzhen 518109, ChinaIron oxide nanoparticles (IONPs) are extensively used in bone-related studies as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, IONPs enter the cell where they promote osteogenic differentiation and inhibit osteoclastogenesis. Static magnetic fields (SMFs) were also found to enhance osteoblast differentiation and hinder osteoclastic differentiation. Once IONPs are exposed to an SMF, they become rapidly magnetized. IONPs and SMFs work together to synergistically enhance the effectiveness of their individual effects on the differentiation and function of osteoblasts and osteoclasts. This article reviewed the individual and combined effects of different types of IONPs and different intensities of SMFs on bone remodeling. We also discussed the mechanism underlying the synergistic effects of IONPs and SMFs on bone remodeling.https://www.mdpi.com/2073-4409/11/20/3298static magnetic fieldsiron oxide nanoparticlesbone remodelingosteoblastosteoclastbone regeneration |
| spellingShingle | Jiancheng Yang Jiawen Wu Zengfeng Guo Gejing Zhang Hao Zhang Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling Cells static magnetic fields iron oxide nanoparticles bone remodeling osteoblast osteoclast bone regeneration |
| title | Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling |
| title_full | Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling |
| title_fullStr | Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling |
| title_full_unstemmed | Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling |
| title_short | Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling |
| title_sort | iron oxide nanoparticles combined with static magnetic fields in bone remodeling |
| topic | static magnetic fields iron oxide nanoparticles bone remodeling osteoblast osteoclast bone regeneration |
| url | https://www.mdpi.com/2073-4409/11/20/3298 |
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