Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality
Abstract Bone implant‐associated infections induced by bacteria frequently result in repair failure and threaten the health of patients. Although black phosphorus (BP) material with superior photothermal conversion ability is booming in the treatment of bone disease, the development of BP‐based bone...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-11-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202204535 |
| _version_ | 1811192777920217088 |
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| author | Yao Zhao Xu Peng Dingqian Wang Hongbo Zhang Qiangwei Xin Mingzhen Wu Xiaoyang Xu Fan Sun Zeyuan Xing Luning Wang Peng Yu Jing Xie Jiehua Li Hong Tan Chunmei Ding Jianshu Li |
| author_facet | Yao Zhao Xu Peng Dingqian Wang Hongbo Zhang Qiangwei Xin Mingzhen Wu Xiaoyang Xu Fan Sun Zeyuan Xing Luning Wang Peng Yu Jing Xie Jiehua Li Hong Tan Chunmei Ding Jianshu Li |
| author_sort | Yao Zhao |
| collection | DOAJ |
| description | Abstract Bone implant‐associated infections induced by bacteria frequently result in repair failure and threaten the health of patients. Although black phosphorus (BP) material with superior photothermal conversion ability is booming in the treatment of bone disease, the development of BP‐based bone scaffolds with excellent photothermal stability and antibacterial properties simultaneously remains a challenge. In nature, chloroplasts cannot only convert light into chemical energy, but also hold a protective and defensive envelope membrane. Inspired by this, a self‐defensive bone scaffold with stable photothermal property is developed for infected bone defect therapy. Similar to thylakoid and stroma lamella in chloroplasts, BP is integrated with chitosan and polycaprolactone fiber networks. The mussel‐inspired polydopamine multifunctional “envelope membrane” wrapped above not only strengthens the photothermal stability of BP‐based scaffolds, but also realizes the in situ anchoring of silver nanoparticles. Bacteria‐triggered infection of femur defects in vivo can be commendably inhibited at the early stage via these chloroplast‐inspired implants, which then effectively promotes endogenous repair of the defect area under mild hyperthermia induced by near‐infrared irradiation. This chloroplast‐inspired strategy shows outstanding performance for infected bone defect therapy and provides a reference for the functionality of other biomedical materials. |
| first_indexed | 2024-04-11T23:57:06Z |
| format | Article |
| id | doaj.art-24fcbe5bc95a4240aa0df2eee20d2b36 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-11T23:57:06Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-24fcbe5bc95a4240aa0df2eee20d2b362022-12-22T03:56:19ZengWileyAdvanced Science2198-38442022-11-01931n/an/a10.1002/advs.202204535Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive FunctionalityYao Zhao0Xu Peng1Dingqian Wang2Hongbo Zhang3Qiangwei Xin4Mingzhen Wu5Xiaoyang Xu6Fan Sun7Zeyuan Xing8Luning Wang9Peng Yu10Jing Xie11Jiehua Li12Hong Tan13Chunmei Ding14Jianshu Li15College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaCollege of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 ChinaAbstract Bone implant‐associated infections induced by bacteria frequently result in repair failure and threaten the health of patients. Although black phosphorus (BP) material with superior photothermal conversion ability is booming in the treatment of bone disease, the development of BP‐based bone scaffolds with excellent photothermal stability and antibacterial properties simultaneously remains a challenge. In nature, chloroplasts cannot only convert light into chemical energy, but also hold a protective and defensive envelope membrane. Inspired by this, a self‐defensive bone scaffold with stable photothermal property is developed for infected bone defect therapy. Similar to thylakoid and stroma lamella in chloroplasts, BP is integrated with chitosan and polycaprolactone fiber networks. The mussel‐inspired polydopamine multifunctional “envelope membrane” wrapped above not only strengthens the photothermal stability of BP‐based scaffolds, but also realizes the in situ anchoring of silver nanoparticles. Bacteria‐triggered infection of femur defects in vivo can be commendably inhibited at the early stage via these chloroplast‐inspired implants, which then effectively promotes endogenous repair of the defect area under mild hyperthermia induced by near‐infrared irradiation. This chloroplast‐inspired strategy shows outstanding performance for infected bone defect therapy and provides a reference for the functionality of other biomedical materials.https://doi.org/10.1002/advs.202204535antimicrobial abilityblack phosphoruschloroplastsosteogenesisself‐defensive |
| spellingShingle | Yao Zhao Xu Peng Dingqian Wang Hongbo Zhang Qiangwei Xin Mingzhen Wu Xiaoyang Xu Fan Sun Zeyuan Xing Luning Wang Peng Yu Jing Xie Jiehua Li Hong Tan Chunmei Ding Jianshu Li Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality Advanced Science antimicrobial ability black phosphorus chloroplasts osteogenesis self‐defensive |
| title | Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality |
| title_full | Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality |
| title_fullStr | Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality |
| title_full_unstemmed | Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality |
| title_short | Chloroplast‐inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self‐Defensive Functionality |
| title_sort | chloroplast inspired scaffold for infected bone defect therapy towards stable photothermal properties and self defensive functionality |
| topic | antimicrobial ability black phosphorus chloroplasts osteogenesis self‐defensive |
| url | https://doi.org/10.1002/advs.202204535 |
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