Structure-Activity Relationships of the Bioactive Thiazinoquinone Marine Natural Products Thiaplidiaquinones A and B

Structure-Activity Relationships of the Bioactive Thiazinoquinone Marine Natural Products Thiaplidiaquinones A and B

In an effort to more accurately define the mechanism of cell death and to establish structure-activity relationship requirements for the marine meroterpenoid alkaloids thiaplidiaquinones A and B, we have evaluated not only the natural products but also dioxothiazine regioisomers and two precursor qu...

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Bibliographic Details
Main Authors: Jacquie L. Harper, Iman M. Khalil, Lisa Shaw, Marie-Lise Bourguet-Kondracki, Joëlle Dubois, Alexis Valentin, David Barker, Brent R. Copp
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Marine Drugs
Subjects:
thiaplidiaquinone
Aplidium
ascidian
thiazinoquinone
apoptosis
Jurkat
cytotoxicity
malaria
farnesyltransferase
Online Access:http://www.mdpi.com/1660-3397/13/8/5102

Internet

http://www.mdpi.com/1660-3397/13/8/5102

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