A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry
Background and Aims: Limited registry studies are available on the use of anesthetic agents. This registry was conducted to evaluate emergence outcomes in Indian adult patients undergoing surgery with desflurane anesthesia. Material and Methods: This multicenter, prospective, non-interventional, obs...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2017;volume=33;issue=2;spage=164;epage=171;aulast=Kapoor |
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| author | Mukul Chandra Kapoor M Radhakrishnan V J Ramesh H S Murthy Dhirja Sharma Parameswara Gundappa Tanmoy Das Ravi Wankhede K Bhaskaran Saiket Sengupta Rajendrasingh Patil Sibasish Dey Kuljinder Singh Ashok K Moharana |
| author_facet | Mukul Chandra Kapoor M Radhakrishnan V J Ramesh H S Murthy Dhirja Sharma Parameswara Gundappa Tanmoy Das Ravi Wankhede K Bhaskaran Saiket Sengupta Rajendrasingh Patil Sibasish Dey Kuljinder Singh Ashok K Moharana |
| author_sort | Mukul Chandra Kapoor |
| collection | DOAJ |
| description | Background and Aims: Limited registry studies are available on the use of anesthetic agents. This registry was conducted to evaluate emergence outcomes in Indian adult patients undergoing surgery with desflurane anesthesia.
Material and Methods: This multicenter, prospective, non-interventional, observational study (Registry in India on Suprane Emergence [RISE] registry) included adult inpatients who received desflurane as general anesthetic for surgical procedure of ≥2 h. Patients were stratified by age into three groups: ≥18–40 years, ≥41–65 years, and >65 years. Data on patients' demographics, practice, and usage pattern of medications were collected. The primary efficacy outcomes were time to extubation, time to response to verbal command, and time to orientation.
Results: Of 236 patients screened, 201 (≥18–40 years, n = 70; ≥41–65 years, n = 65; >65 years, n = 66) were enrolled in the study. Mean time to extubation observed in ≥18–40 years group was 7.2 ± 4.1 min, ≥41–65 years was 11.6 ± 8.99 min, and >65 years was 12.0 ± 10.5 min. Mean time to response to verbal command was 7.4 ± 4.3 min for ≥18–40 years, 10.9 ± 8.5 min for ≥41–65 years, and 10.0 ± 5.4 min for >65 years. Mean time to orientation was 13.0 ± 7.0 min for ≥18–40 years, 16.1 ± 12.0 min for ≥41–65 years, and 17.0 ± 8.6 min for >65 years. Incidence of nausea and retching/vomiting was observed in 8% of patients each in the postoperative period, and these complications were seen more in the >65 years age group. Overall, desflurane treatment maintained hemodynamic stability and no major airway events were reported.
Conclusions: The RISE registry data suggest that desflurane-based anesthesia provides early recovery with stable hemodynamics without any airway adverse events, in a wide variety of surgical procedures. |
| first_indexed | 2024-04-12T09:27:41Z |
| format | Article |
| id | doaj.art-2500448fdbc74ac4a5be24063831b9a3 |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-04-12T09:27:41Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-2500448fdbc74ac4a5be24063831b9a32022-12-22T03:38:26ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852017-01-0133216417110.4103/joacp.JOACP_350_16A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registryMukul Chandra KapoorM RadhakrishnanV J RameshH S MurthyDhirja SharmaParameswara GundappaTanmoy DasRavi WankhedeK BhaskaranSaiket SenguptaRajendrasingh PatilSibasish DeyKuljinder SinghAshok K MoharanaBackground and Aims: Limited registry studies are available on the use of anesthetic agents. This registry was conducted to evaluate emergence outcomes in Indian adult patients undergoing surgery with desflurane anesthesia. Material and Methods: This multicenter, prospective, non-interventional, observational study (Registry in India on Suprane Emergence [RISE] registry) included adult inpatients who received desflurane as general anesthetic for surgical procedure of ≥2 h. Patients were stratified by age into three groups: ≥18–40 years, ≥41–65 years, and >65 years. Data on patients' demographics, practice, and usage pattern of medications were collected. The primary efficacy outcomes were time to extubation, time to response to verbal command, and time to orientation. Results: Of 236 patients screened, 201 (≥18–40 years, n = 70; ≥41–65 years, n = 65; >65 years, n = 66) were enrolled in the study. Mean time to extubation observed in ≥18–40 years group was 7.2 ± 4.1 min, ≥41–65 years was 11.6 ± 8.99 min, and >65 years was 12.0 ± 10.5 min. Mean time to response to verbal command was 7.4 ± 4.3 min for ≥18–40 years, 10.9 ± 8.5 min for ≥41–65 years, and 10.0 ± 5.4 min for >65 years. Mean time to orientation was 13.0 ± 7.0 min for ≥18–40 years, 16.1 ± 12.0 min for ≥41–65 years, and 17.0 ± 8.6 min for >65 years. Incidence of nausea and retching/vomiting was observed in 8% of patients each in the postoperative period, and these complications were seen more in the >65 years age group. Overall, desflurane treatment maintained hemodynamic stability and no major airway events were reported. Conclusions: The RISE registry data suggest that desflurane-based anesthesia provides early recovery with stable hemodynamics without any airway adverse events, in a wide variety of surgical procedures.http://www.joacp.org/article.asp?issn=0970-9185;year=2017;volume=33;issue=2;spage=164;epage=171;aulast=KapoorAnesthesia recoverydesfluraneobservational studyoptimized pathwaysregistry |
| spellingShingle | Mukul Chandra Kapoor M Radhakrishnan V J Ramesh H S Murthy Dhirja Sharma Parameswara Gundappa Tanmoy Das Ravi Wankhede K Bhaskaran Saiket Sengupta Rajendrasingh Patil Sibasish Dey Kuljinder Singh Ashok K Moharana A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry Journal of Anaesthesiology Clinical Pharmacology Anesthesia recovery desflurane observational study optimized pathways registry |
| title | A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry |
| title_full | A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry |
| title_fullStr | A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry |
| title_full_unstemmed | A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry |
| title_short | A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry |
| title_sort | prospective observational study of the use of desflurane anesthesia in indian adult inpatients undergoing surgery the registry in india on suprane emergence registry |
| topic | Anesthesia recovery desflurane observational study optimized pathways registry |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2017;volume=33;issue=2;spage=164;epage=171;aulast=Kapoor |
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