Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention
Abstract Traditional remedies using natural ingredients have been handed down over generations, providing collective information for the development of modern therapeutics. These natural products have a long history of safe consumption with curative effects but lack of scientific-based evidence hind...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49074-5 |
| _version_ | 1797397994979459072 |
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| author | Nattira On-Nom Sirinapa Thangsiri Woorawee Inthachat Piya Temviriyanukul Piyapat Trisonthi Chaowanee Chupeerach Dalad Siriwan Uthaiwan Suttisansanee |
| author_facet | Nattira On-Nom Sirinapa Thangsiri Woorawee Inthachat Piya Temviriyanukul Piyapat Trisonthi Chaowanee Chupeerach Dalad Siriwan Uthaiwan Suttisansanee |
| author_sort | Nattira On-Nom |
| collection | DOAJ |
| description | Abstract Traditional remedies using natural ingredients have been handed down over generations, providing collective information for the development of modern therapeutics. These natural products have a long history of safe consumption with curative effects but lack of scientific-based evidence hinders the mass production of new remedies containing active ingredients with particular medicinal properties. This research investigated the phenolic profiles and biochemical properties of 29 herbal ingredients identified in two traditional Thai remedies, Prasachandaeng (PSCD) and Chantaharuethai (CHRT), and their effectiveness in combating chronic diseases. These two traditional remedies are used to reduce fever but some ingredients have been previously reported to possess other health-related properties. Statistical analysis by TOPSIS indicated that Biancaea sappan (L.) Tod. extract exhibited the highest overall closeness coefficient (C) score analyzed from all variables including total phenolic contents, antioxidant potentials, and enzyme inhibitions. Bouea macrophylla Griff. extract showed potential as an effective agent against diabetes through inhibition of two carbohydrate degrading enzymes, α-glucosidase and α-amylase, while Dischidia major (Vahl) Merr. showed strong properties as an anti-angiotensin-converting enzyme, leading to the control of hypertension. Dracaena cochinchinensis (Lour.) S.C. Chen effectively controlled the progression of Alzheimer’s disease through the inhibition of cholinergic and β-amyloid formation enzymes. These results can be used as preliminary data for the development of new remedies to prevent or treat particular chronic diseases. |
| first_indexed | 2024-03-09T01:19:16Z |
| format | Article |
| id | doaj.art-25006744267442938aded04acf4a2a96 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T01:19:16Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-25006744267442938aded04acf4a2a962023-12-10T12:15:59ZengNature PortfolioScientific Reports2045-23222023-12-0113111310.1038/s41598-023-49074-5Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases preventionNattira On-Nom0Sirinapa Thangsiri1Woorawee Inthachat2Piya Temviriyanukul3Piyapat Trisonthi4Chaowanee Chupeerach5Dalad Siriwan6Uthaiwan Suttisansanee7Food and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol UniversityFood and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol UniversityFood and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol UniversityFood and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol UniversityInstitute of Food Research and Product Development, Kasetsart UniversityFood and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol UniversityInstitute of Food Research and Product Development, Kasetsart UniversityFood and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol UniversityAbstract Traditional remedies using natural ingredients have been handed down over generations, providing collective information for the development of modern therapeutics. These natural products have a long history of safe consumption with curative effects but lack of scientific-based evidence hinders the mass production of new remedies containing active ingredients with particular medicinal properties. This research investigated the phenolic profiles and biochemical properties of 29 herbal ingredients identified in two traditional Thai remedies, Prasachandaeng (PSCD) and Chantaharuethai (CHRT), and their effectiveness in combating chronic diseases. These two traditional remedies are used to reduce fever but some ingredients have been previously reported to possess other health-related properties. Statistical analysis by TOPSIS indicated that Biancaea sappan (L.) Tod. extract exhibited the highest overall closeness coefficient (C) score analyzed from all variables including total phenolic contents, antioxidant potentials, and enzyme inhibitions. Bouea macrophylla Griff. extract showed potential as an effective agent against diabetes through inhibition of two carbohydrate degrading enzymes, α-glucosidase and α-amylase, while Dischidia major (Vahl) Merr. showed strong properties as an anti-angiotensin-converting enzyme, leading to the control of hypertension. Dracaena cochinchinensis (Lour.) S.C. Chen effectively controlled the progression of Alzheimer’s disease through the inhibition of cholinergic and β-amyloid formation enzymes. These results can be used as preliminary data for the development of new remedies to prevent or treat particular chronic diseases.https://doi.org/10.1038/s41598-023-49074-5 |
| spellingShingle | Nattira On-Nom Sirinapa Thangsiri Woorawee Inthachat Piya Temviriyanukul Piyapat Trisonthi Chaowanee Chupeerach Dalad Siriwan Uthaiwan Suttisansanee Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention Scientific Reports |
| title | Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention |
| title_full | Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention |
| title_fullStr | Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention |
| title_full_unstemmed | Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention |
| title_short | Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention |
| title_sort | phenolic profiles and in vitro biochemical properties of thai herb ingredients for chronic diseases prevention |
| url | https://doi.org/10.1038/s41598-023-49074-5 |
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