Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity
A 44-year-old woman with no significant medical history presented with a 3-week history of high-grade fevers, fatigue and shortness of breath. Laboratory investigation was significant for lymphopenia and thrombocytopenia which progressively worsened during her hospital stay, along with new-onset ana...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2020-08-01
|
| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/1850 |
| _version_ | 1818870524446507008 |
|---|---|
| author | Mohammad Ammad Ud Din Syed Ather Hussain Bassil Said Aneeqa Zafar |
| author_facet | Mohammad Ammad Ud Din Syed Ather Hussain Bassil Said Aneeqa Zafar |
| author_sort | Mohammad Ammad Ud Din |
| collection | DOAJ |
| description | A 44-year-old woman with no significant medical history presented with a 3-week history of high-grade fevers, fatigue and shortness of breath. Laboratory investigation was significant for lymphopenia and thrombocytopenia which progressively worsened during her hospital stay, along with new-onset anaemia, and elevated ferritin, transaminase and triglycerides. A computerized tomography (CT) scan of the abdomen revealed retroperitoneal lymphadenopathy. A bone marrow biopsy confirmed the diagnosis of haemophagocytic lymphohistiocytosis (HLH). Extensive infectious work-up revealed high IgG titres for Bartonella henselae and Coxiella burnetii. Interestingly, the left supraclavicular node was negative for both microbes by polymerase chain reaction (PCR), but the biopsy revealed anaplastic large T-cell lymphoma. |
| first_indexed | 2024-12-19T12:08:24Z |
| format | Article |
| id | doaj.art-2501053aa76e495da293de1009d31327 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-19T12:08:24Z |
| publishDate | 2020-08-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-2501053aa76e495da293de1009d313272022-12-21T20:22:16ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942020-08-0110.12890/2020_0018501473Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae SeropositivityMohammad Ammad Ud Din0Syed Ather Hussain1Bassil Said2Aneeqa Zafar3Department of Internal Medicine, Rochester General Hospital, New York, USA Department of Internal Medicine, Rochester General Hospital, New York, USA Department of Internal Medicine, Rochester General Hospital, New York, USA Department of Hospitalist Medicine, El Camino Hospital, Mountain View, California, USAA 44-year-old woman with no significant medical history presented with a 3-week history of high-grade fevers, fatigue and shortness of breath. Laboratory investigation was significant for lymphopenia and thrombocytopenia which progressively worsened during her hospital stay, along with new-onset anaemia, and elevated ferritin, transaminase and triglycerides. A computerized tomography (CT) scan of the abdomen revealed retroperitoneal lymphadenopathy. A bone marrow biopsy confirmed the diagnosis of haemophagocytic lymphohistiocytosis (HLH). Extensive infectious work-up revealed high IgG titres for Bartonella henselae and Coxiella burnetii. Interestingly, the left supraclavicular node was negative for both microbes by polymerase chain reaction (PCR), but the biopsy revealed anaplastic large T-cell lymphoma.https://www.ejcrim.com/index.php/EJCRIM/article/view/1850haemophagocytic lymphohistiocytosiscoxiella burnetiibartonella henselae t-cell lymphoma |
| spellingShingle | Mohammad Ammad Ud Din Syed Ather Hussain Bassil Said Aneeqa Zafar Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity European Journal of Case Reports in Internal Medicine haemophagocytic lymphohistiocytosis coxiella burnetii bartonella henselae t-cell lymphoma |
| title | Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity |
| title_full | Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity |
| title_fullStr | Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity |
| title_full_unstemmed | Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity |
| title_short | Anaplastic Large Cell Lymphoma Presenting as Haemophagocytic Lymphohistiocytosis with Underlying Coxiella burnetii and Bartonella henselae Seropositivity |
| title_sort | anaplastic large cell lymphoma presenting as haemophagocytic lymphohistiocytosis with underlying coxiella burnetii and bartonella henselae seropositivity |
| topic | haemophagocytic lymphohistiocytosis coxiella burnetii bartonella henselae t-cell lymphoma |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/1850 |
| work_keys_str_mv | AT mohammadammaduddin anaplasticlargecelllymphomapresentingashaemophagocyticlymphohistiocytosiswithunderlyingcoxiellaburnetiiandbartonellahenselaeseropositivity AT syedatherhussain anaplasticlargecelllymphomapresentingashaemophagocyticlymphohistiocytosiswithunderlyingcoxiellaburnetiiandbartonellahenselaeseropositivity AT bassilsaid anaplasticlargecelllymphomapresentingashaemophagocyticlymphohistiocytosiswithunderlyingcoxiellaburnetiiandbartonellahenselaeseropositivity AT aneeqazafar anaplasticlargecelllymphomapresentingashaemophagocyticlymphohistiocytosiswithunderlyingcoxiellaburnetiiandbartonellahenselaeseropositivity |