Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional material
Radix Astragali, one of the most popular herbs in traditional Chinese medicine (TCM), is used to strengthen the immune system, protect liver function, fight bacteria and viruses, and treat diabetes, heart failure and seasonal allergies. In recent years, a new form of Radix Astragali material process...
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| Format: | Article |
| Language: | English |
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Maximum Academic Press
2022-01-01
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| Series: | Medicinal Plant Biology |
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| Online Access: | https://www.maxapress.com/article/doi/10.48130/MPB-2022-0004 |
| _version_ | 1797279307318427648 |
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| author | Liang Cao Mei Wang Jianping Zhao Li-Hua Peng Jin-Le Cheng Shi Qiu Ikhlas A. Khan Xing-Cong Li |
| author_facet | Liang Cao Mei Wang Jianping Zhao Li-Hua Peng Jin-Le Cheng Shi Qiu Ikhlas A. Khan Xing-Cong Li |
| author_sort | Liang Cao |
| collection | DOAJ |
| description | Radix Astragali, one of the most popular herbs in traditional Chinese medicine (TCM), is used to strengthen the immune system, protect liver function, fight bacteria and viruses, and treat diabetes, heart failure and seasonal allergies. In recent years, a new form of Radix Astragali material processed by cell wall disrupting technology, namely ultrafine granular powder (UGP) has been introduced into the market. In order to determine chemical consistency and homogeneity of the UGP material prepared from sliced traditional materials (TM) of Radix Astragali, multiple batches of the UGP and TM samples derived from Astragalus membranaceus var. mongholicus were analyzed by UHPLC/DAD-MS using isoflavones and triterpenoid glycosides as marker compounds. The results demonstrated that the chemical profiles of UGP was identical or similar to that of TM, but UGP was highly homogeneous in terms of marker compound contents as assessed, e.g., by the relative standard deviation values of the nine marker compounds in the range of 8.55%−43.80% for TM2 compared against 1.70%−8.38% for UGP2. Macromolecular component preparation and 1H NMR analyses indicated that TM4 and its corresponding UGP4 produced similar polysaccharides, but the later had approximately two-fold dissolution rate of the polysaccharides when compared to the former (yield 7.22 ± 0.35% vs 3.39 ± 0.20%). This study confirms that UGP of Radix Astragali is chemically consistent and homogenous, supporting its use as a promising material in TCM prescriptions. |
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| format | Article |
| id | doaj.art-2504e57f6a504a4884c61131401d97d6 |
| institution | Directory Open Access Journal |
| issn | 2835-6969 |
| language | English |
| last_indexed | 2024-03-07T16:23:23Z |
| publishDate | 2022-01-01 |
| publisher | Maximum Academic Press |
| record_format | Article |
| series | Medicinal Plant Biology |
| spelling | doaj.art-2504e57f6a504a4884c61131401d97d62024-03-04T01:28:09ZengMaximum Academic PressMedicinal Plant Biology2835-69692022-01-01111710.48130/MPB-2022-0004MPB-2022-0004Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional materialLiang Cao0Mei Wang1Jianping Zhao2Li-Hua Peng3Jin-Le Cheng4Shi Qiu5Ikhlas A. Khan6Xing-Cong Li7National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USANatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture, University, Mississippi 38677, USANational Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USAKey Laboratory of Technologies and Applications of Ultrafine Granular Powder of Herbal Medicine, State Administration of Traditional Chinese Medicine, Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd. Zhongshan 528437, P. R. ChinaKey Laboratory of Technologies and Applications of Ultrafine Granular Powder of Herbal Medicine, State Administration of Traditional Chinese Medicine, Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd. Zhongshan 528437, P. R. ChinaNational Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USANational Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USANational Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USARadix Astragali, one of the most popular herbs in traditional Chinese medicine (TCM), is used to strengthen the immune system, protect liver function, fight bacteria and viruses, and treat diabetes, heart failure and seasonal allergies. In recent years, a new form of Radix Astragali material processed by cell wall disrupting technology, namely ultrafine granular powder (UGP) has been introduced into the market. In order to determine chemical consistency and homogeneity of the UGP material prepared from sliced traditional materials (TM) of Radix Astragali, multiple batches of the UGP and TM samples derived from Astragalus membranaceus var. mongholicus were analyzed by UHPLC/DAD-MS using isoflavones and triterpenoid glycosides as marker compounds. The results demonstrated that the chemical profiles of UGP was identical or similar to that of TM, but UGP was highly homogeneous in terms of marker compound contents as assessed, e.g., by the relative standard deviation values of the nine marker compounds in the range of 8.55%−43.80% for TM2 compared against 1.70%−8.38% for UGP2. Macromolecular component preparation and 1H NMR analyses indicated that TM4 and its corresponding UGP4 produced similar polysaccharides, but the later had approximately two-fold dissolution rate of the polysaccharides when compared to the former (yield 7.22 ± 0.35% vs 3.39 ± 0.20%). This study confirms that UGP of Radix Astragali is chemically consistent and homogenous, supporting its use as a promising material in TCM prescriptions.https://www.maxapress.com/article/doi/10.48130/MPB-2022-0004radix astragaliultrafine granular powderisoflavonestriterpenoid glycosidespolysaccharides |
| spellingShingle | Liang Cao Mei Wang Jianping Zhao Li-Hua Peng Jin-Le Cheng Shi Qiu Ikhlas A. Khan Xing-Cong Li Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional material Medicinal Plant Biology radix astragali ultrafine granular powder isoflavones triterpenoid glycosides polysaccharides |
| title | Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional material |
| title_full | Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional material |
| title_fullStr | Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional material |
| title_full_unstemmed | Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional material |
| title_short | Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and sliced traditional material |
| title_sort | comparative analysis of chemical profiles of radix astragali between ultrafine granular powder and sliced traditional material |
| topic | radix astragali ultrafine granular powder isoflavones triterpenoid glycosides polysaccharides |
| url | https://www.maxapress.com/article/doi/10.48130/MPB-2022-0004 |
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