Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy
Abstract Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoing challenge. In this work, an extraordinary injectable hydrogel PBNPs@OBG (Prussia...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-022-01633-0 |
| _version_ | 1797998292778352640 |
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| author | Linjun Yang Congcong Yu Xuhui Fan Tianni Zeng Wentao Yang Jiechao Xia Jianle Wang Litao Yao Chuan Hu Yang Jin Yutao Zhu Jiaxin Chen Zhijun Hu |
| author_facet | Linjun Yang Congcong Yu Xuhui Fan Tianni Zeng Wentao Yang Jiechao Xia Jianle Wang Litao Yao Chuan Hu Yang Jin Yutao Zhu Jiaxin Chen Zhijun Hu |
| author_sort | Linjun Yang |
| collection | DOAJ |
| description | Abstract Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoing challenge. In this work, an extraordinary injectable hydrogel PBNPs@OBG (Prussian blue nanoparticles@oxidized hyaluronic acid/borax/gelatin) with promising antibacterial, antioxidation, rapid gelation, and self-healing characteristics was designed via dual-dynamic-bond cross-linking among the oxidized hyaluronic acid (OHA), borax, and gelatin. The mechanical performance of the hydrogel was studied by dynamic mechanical analysis. Meanwhile, the swelling ratio and degradation level of the hydrogel was explored. Benefiting from its remarkable mechanical properties, sufficient tissue adhesiveness, and ideal shape-adaptability, the injectable PBNPs containing hydrogel was explored for IVDD therapy. Astoundingly, the as-fabricated hydrogel was able to alleviate H2O2-induced excessive ROS against oxidative stress trauma of nucleus pulposus, which was further revealed by theoretical calculations. Rat IVDD model was next established to estimate therapeutic effect of this PBNPs@OBG hydrogel for IVDD treatment in vivo. On the whole, combination of the smart multifunctional hydrogel and nanotechnology-mediated antioxidant therapy can serve as a fire-new general type of therapeutic strategy for IVDD and other oxidative stress-related diseases. |
| first_indexed | 2024-04-11T10:46:23Z |
| format | Article |
| id | doaj.art-2505cf28b98d4827a0ea90ad7dd5e1ee |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T10:46:23Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-2505cf28b98d4827a0ea90ad7dd5e1ee2022-12-22T04:29:03ZengBMCJournal of Nanobiotechnology1477-31552022-10-0120111810.1186/s12951-022-01633-0Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapyLinjun Yang0Congcong Yu1Xuhui Fan2Tianni Zeng3Wentao Yang4Jiechao Xia5Jianle Wang6Litao Yao7Chuan Hu8Yang Jin9Yutao Zhu10Jiaxin Chen11Zhijun Hu12Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Oncology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical UniversityDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Dentistry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang UniversityDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Key Laboratory of Musculoskeletal System Degeneration, Regeneration Translational Research of Zhejiang Province, Zhejiang University School of MedicineAbstract Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoing challenge. In this work, an extraordinary injectable hydrogel PBNPs@OBG (Prussian blue nanoparticles@oxidized hyaluronic acid/borax/gelatin) with promising antibacterial, antioxidation, rapid gelation, and self-healing characteristics was designed via dual-dynamic-bond cross-linking among the oxidized hyaluronic acid (OHA), borax, and gelatin. The mechanical performance of the hydrogel was studied by dynamic mechanical analysis. Meanwhile, the swelling ratio and degradation level of the hydrogel was explored. Benefiting from its remarkable mechanical properties, sufficient tissue adhesiveness, and ideal shape-adaptability, the injectable PBNPs containing hydrogel was explored for IVDD therapy. Astoundingly, the as-fabricated hydrogel was able to alleviate H2O2-induced excessive ROS against oxidative stress trauma of nucleus pulposus, which was further revealed by theoretical calculations. Rat IVDD model was next established to estimate therapeutic effect of this PBNPs@OBG hydrogel for IVDD treatment in vivo. On the whole, combination of the smart multifunctional hydrogel and nanotechnology-mediated antioxidant therapy can serve as a fire-new general type of therapeutic strategy for IVDD and other oxidative stress-related diseases.https://doi.org/10.1186/s12951-022-01633-0Dual-dynamic-bond cross-linkedMultifunctional hydrogelOxidative stress-related diseaseMinimally invasive therapy |
| spellingShingle | Linjun Yang Congcong Yu Xuhui Fan Tianni Zeng Wentao Yang Jiechao Xia Jianle Wang Litao Yao Chuan Hu Yang Jin Yutao Zhu Jiaxin Chen Zhijun Hu Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy Journal of Nanobiotechnology Dual-dynamic-bond cross-linked Multifunctional hydrogel Oxidative stress-related disease Minimally invasive therapy |
| title | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
| title_full | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
| title_fullStr | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
| title_full_unstemmed | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
| title_short | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
| title_sort | dual dynamic bond cross linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
| topic | Dual-dynamic-bond cross-linked Multifunctional hydrogel Oxidative stress-related disease Minimally invasive therapy |
| url | https://doi.org/10.1186/s12951-022-01633-0 |
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