FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer
Biological markers that could predict the progression of ductal carcinoma in-situ (DCIS) to invasive breast cancer (IDC) are required urgently for personalized therapy for patients diagnosed with DCIS. As stroma was invaded by malignant cells, perturbed stromal-epithelial interactions would bring ab...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01424/full |
| _version_ | 1819265559803461632 |
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| author | Li-Na Yu Li-Na Yu Li-Na Yu Zhen Liu Yan Tian Yan Tian Yan Tian Pei-Pei Zhao Pei-Pei Zhao Pei-Pei Zhao Xing Hua |
| author_facet | Li-Na Yu Li-Na Yu Li-Na Yu Zhen Liu Yan Tian Yan Tian Yan Tian Pei-Pei Zhao Pei-Pei Zhao Pei-Pei Zhao Xing Hua |
| author_sort | Li-Na Yu |
| collection | DOAJ |
| description | Biological markers that could predict the progression of ductal carcinoma in-situ (DCIS) to invasive breast cancer (IDC) are required urgently for personalized therapy for patients diagnosed with DCIS. As stroma was invaded by malignant cells, perturbed stromal-epithelial interactions would bring about tissue remodeling. With the specific expression of the fibroblast activation protein-alpha (FAP-a), Carcinoma-associated fibroblasts (CAFs) are the main cell populations in the remodeled tumor stroma. Golgi phosphoprotein 3 (GOLPH3), a documented oncogene possessing potent transforming capacity, is not only up-regulated in many tumors but also an efficient indicator of poor prognosis and more malignant tumors. The present study aimed to retrospectively evaluate the pathological value of FAP-a and GOLPH3 in predicting the recurrence or progression of DCIS to invasive breast cancer. Immunohistochemical techniques were applied to investigate the expression of FAP-a GOLPH3 in 449 cases of DCIS patients received extensive resection and with close follow-up, but not being treated with any form of chemo- or radio-therapy. The combination of FAP-a and GOLPH3 in predicating the recurrence or progression of DCIS into invasive breast cancer was specifically examined. The study demonstrated that the overexpression of FAP-a in stromal fibroblasts and GOLPH3 in carcinoma cells are highly predictive of DCIS recurrence and progression into invasive breast cancer. Both FAP-a and GOLPH3 have high specificity and sensitivity to predict the recurrence of DCIS. Moreover, the combination of FAP-a and GOLPH3 tends to further improve the specificity and sensitivity of DCIS recurrence by 9.72–10.31 and 2.72–3.63%, respectively. FAP-a and GOLPH3 serve as novel markers in predicting the recurrence or progression of DCIS into invasive breast cancer. |
| first_indexed | 2024-12-23T20:47:19Z |
| format | Article |
| id | doaj.art-2506343610cb4c56915a4af698ead5ae |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T20:47:19Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2506343610cb4c56915a4af698ead5ae2022-12-21T17:31:45ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-12-01910.3389/fonc.2019.01424476308FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast CancerLi-Na Yu0Li-Na Yu1Li-Na Yu2Zhen Liu3Yan Tian4Yan Tian5Yan Tian6Pei-Pei Zhao7Pei-Pei Zhao8Pei-Pei Zhao9Xing Hua10Department of Pathology, Nanfang Hospital, Guangzhou, ChinaDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, ChinaDepartment of Pathology, School of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Pathology, Nanfang Hospital, Guangzhou, ChinaDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, ChinaDepartment of Pathology, Nanfang Hospital, Guangzhou, ChinaDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, ChinaDepartment of Pathology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, ChinaBiological markers that could predict the progression of ductal carcinoma in-situ (DCIS) to invasive breast cancer (IDC) are required urgently for personalized therapy for patients diagnosed with DCIS. As stroma was invaded by malignant cells, perturbed stromal-epithelial interactions would bring about tissue remodeling. With the specific expression of the fibroblast activation protein-alpha (FAP-a), Carcinoma-associated fibroblasts (CAFs) are the main cell populations in the remodeled tumor stroma. Golgi phosphoprotein 3 (GOLPH3), a documented oncogene possessing potent transforming capacity, is not only up-regulated in many tumors but also an efficient indicator of poor prognosis and more malignant tumors. The present study aimed to retrospectively evaluate the pathological value of FAP-a and GOLPH3 in predicting the recurrence or progression of DCIS to invasive breast cancer. Immunohistochemical techniques were applied to investigate the expression of FAP-a GOLPH3 in 449 cases of DCIS patients received extensive resection and with close follow-up, but not being treated with any form of chemo- or radio-therapy. The combination of FAP-a and GOLPH3 in predicating the recurrence or progression of DCIS into invasive breast cancer was specifically examined. The study demonstrated that the overexpression of FAP-a in stromal fibroblasts and GOLPH3 in carcinoma cells are highly predictive of DCIS recurrence and progression into invasive breast cancer. Both FAP-a and GOLPH3 have high specificity and sensitivity to predict the recurrence of DCIS. Moreover, the combination of FAP-a and GOLPH3 tends to further improve the specificity and sensitivity of DCIS recurrence by 9.72–10.31 and 2.72–3.63%, respectively. FAP-a and GOLPH3 serve as novel markers in predicting the recurrence or progression of DCIS into invasive breast cancer.https://www.frontiersin.org/article/10.3389/fonc.2019.01424/fullFAP-aGOLPH3DCISrecurrencebreast cancer |
| spellingShingle | Li-Na Yu Li-Na Yu Li-Na Yu Zhen Liu Yan Tian Yan Tian Yan Tian Pei-Pei Zhao Pei-Pei Zhao Pei-Pei Zhao Xing Hua FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer Frontiers in Oncology FAP-a GOLPH3 DCIS recurrence breast cancer |
| title | FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer |
| title_full | FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer |
| title_fullStr | FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer |
| title_full_unstemmed | FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer |
| title_short | FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer |
| title_sort | fap a and golph3 are hallmarks of dcis progression to invasive breast cancer |
| topic | FAP-a GOLPH3 DCIS recurrence breast cancer |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.01424/full |
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