Biological role of matrix stiffness in tumor growth and treatment
Abstract In recent years, the biological role of changes in physical factors in carcinogenesis and progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is a critical physical factor of tumor microenvironment and remains alternating during carcinogenesis as a re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03768-y |
| _version_ | 1811186994321031168 |
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| author | Boer Deng Ziyi Zhao Weimin Kong Chao Han Xiaochang Shen Chunxiao Zhou |
| author_facet | Boer Deng Ziyi Zhao Weimin Kong Chao Han Xiaochang Shen Chunxiao Zhou |
| author_sort | Boer Deng |
| collection | DOAJ |
| description | Abstract In recent years, the biological role of changes in physical factors in carcinogenesis and progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is a critical physical factor of tumor microenvironment and remains alternating during carcinogenesis as a result of ECM remodeling through activation of cancer-associated fibroblasts and extracellular collagen accumulation, crosslinking and fibrosis. Different content and density of extracellular collagen in ECM endows matrix with varying stiffness. Physical signals induced by matrix stiffness are transmitted to tumor cells primarily by the integrins receptor family and trigger a series of mechanotransduction that result in changes in tumor cell morphology, proliferative capacity, and invasive ability. Importantly, accumulating evidence revealed that changes in matrix stiffness in tumor tissues greatly control the sensitivity of tumor cells in response to chemotherapy, radiotherapy, and immunotherapy through integrin signaling, YAP signaling, and related signaling pathways. Here, the present review analyzes the current research advances on matrix stiffness and tumor cell behavior with a view to contributing to tumor cell growth and treatment, with the hope of improving the understanding of the biological role of matrix stiffness in tumors. |
| first_indexed | 2024-04-11T13:54:36Z |
| format | Article |
| id | doaj.art-25078a19fb6f4929a55a7a47063db781 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-11T13:54:36Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-25078a19fb6f4929a55a7a47063db7812022-12-22T04:20:22ZengBMCJournal of Translational Medicine1479-58762022-11-0120111510.1186/s12967-022-03768-yBiological role of matrix stiffness in tumor growth and treatmentBoer Deng0Ziyi Zhao1Weimin Kong2Chao Han3Xiaochang Shen4Chunxiao Zhou5Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care HospitalDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care HospitalDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care HospitalDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care HospitalDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care HospitalDivision of Gynecologic Oncology, University of North Carolina at Chapel HillAbstract In recent years, the biological role of changes in physical factors in carcinogenesis and progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is a critical physical factor of tumor microenvironment and remains alternating during carcinogenesis as a result of ECM remodeling through activation of cancer-associated fibroblasts and extracellular collagen accumulation, crosslinking and fibrosis. Different content and density of extracellular collagen in ECM endows matrix with varying stiffness. Physical signals induced by matrix stiffness are transmitted to tumor cells primarily by the integrins receptor family and trigger a series of mechanotransduction that result in changes in tumor cell morphology, proliferative capacity, and invasive ability. Importantly, accumulating evidence revealed that changes in matrix stiffness in tumor tissues greatly control the sensitivity of tumor cells in response to chemotherapy, radiotherapy, and immunotherapy through integrin signaling, YAP signaling, and related signaling pathways. Here, the present review analyzes the current research advances on matrix stiffness and tumor cell behavior with a view to contributing to tumor cell growth and treatment, with the hope of improving the understanding of the biological role of matrix stiffness in tumors.https://doi.org/10.1186/s12967-022-03768-yMatrix stiffnessCell proliferationApoptosisCancer therapy |
| spellingShingle | Boer Deng Ziyi Zhao Weimin Kong Chao Han Xiaochang Shen Chunxiao Zhou Biological role of matrix stiffness in tumor growth and treatment Journal of Translational Medicine Matrix stiffness Cell proliferation Apoptosis Cancer therapy |
| title | Biological role of matrix stiffness in tumor growth and treatment |
| title_full | Biological role of matrix stiffness in tumor growth and treatment |
| title_fullStr | Biological role of matrix stiffness in tumor growth and treatment |
| title_full_unstemmed | Biological role of matrix stiffness in tumor growth and treatment |
| title_short | Biological role of matrix stiffness in tumor growth and treatment |
| title_sort | biological role of matrix stiffness in tumor growth and treatment |
| topic | Matrix stiffness Cell proliferation Apoptosis Cancer therapy |
| url | https://doi.org/10.1186/s12967-022-03768-y |
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