Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population
Introduction. The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population.Therefore, we investigated the association of the ACE gene insertion/...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2009-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320309104873 |
| _version_ | 1797285111201267712 |
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| author | Jian-Kang Yang Yuan-Ying Gong Liang Xie Shi-Gang Lian Juan Yang Liang-You Xu Shou-Jun Gao Ya-Ping Zhang |
| author_facet | Jian-Kang Yang Yuan-Ying Gong Liang Xie Shi-Gang Lian Juan Yang Liang-You Xu Shou-Jun Gao Ya-Ping Zhang |
| author_sort | Jian-Kang Yang |
| collection | DOAJ |
| description | Introduction. The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population.Therefore, we investigated the association of the ACE gene insertion/ deletion polymorphism with longevity in a Han Chinese population. Materials and methods. We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years. Results. No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group.When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884). Conclusions. No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population. |
| first_indexed | 2024-03-07T17:57:31Z |
| format | Article |
| id | doaj.art-25081f984338405992e06ac6363a1242 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T17:57:31Z |
| publishDate | 2009-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-25081f984338405992e06ac6363a12422024-03-02T11:36:04ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032009-06-011010.1177/1470320309104873Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese populationJian-Kang YangYuan-Ying Gong Liang XieShi-Gang Lian Juan YangLiang-You XuShou-Jun GaoYa-Ping ZhangIntroduction. The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population.Therefore, we investigated the association of the ACE gene insertion/ deletion polymorphism with longevity in a Han Chinese population. Materials and methods. We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years. Results. No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group.When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884). Conclusions. No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population.https://doi.org/10.1177/1470320309104873 |
| spellingShingle | Jian-Kang Yang Yuan-Ying Gong Liang Xie Shi-Gang Lian Juan Yang Liang-You Xu Shou-Jun Gao Ya-Ping Zhang Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population Journal of the Renin-Angiotensin-Aldosterone System |
| title | Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population |
| title_full | Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population |
| title_fullStr | Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population |
| title_full_unstemmed | Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population |
| title_short | Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population |
| title_sort | lack of genetic association between the angiotensin converting enzyme gene insertion deletion polymorphism and longevity in a han chinese population |
| url | https://doi.org/10.1177/1470320309104873 |
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