The role of aldosterone in the pathogenesis of diabetic retinopathy
Aldosterone, as a mineralocorticoid of adrenal origin, has effects that are not limited to the urinary tract. As an important regulator in Vasoactive hormone pathways, aldosterone may play an effect in the pathogenesis of diabetic retinopathy (DR) through the regulation of oxidative stress, vascular...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1163787/full |
| _version_ | 1797849157366448128 |
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| author | Kangcheng Liu Hua Zou Huimin Fan Hanying Hu Yanhua Cheng Jingying Liu Xiaojian Wu Bolin Chen Zhipeng You |
| author_facet | Kangcheng Liu Hua Zou Huimin Fan Hanying Hu Yanhua Cheng Jingying Liu Xiaojian Wu Bolin Chen Zhipeng You |
| author_sort | Kangcheng Liu |
| collection | DOAJ |
| description | Aldosterone, as a mineralocorticoid of adrenal origin, has effects that are not limited to the urinary tract. As an important regulator in Vasoactive hormone pathways, aldosterone may play an effect in the pathogenesis of diabetic retinopathy (DR) through the regulation of oxidative stress, vascular regulation, and inflammatory mechanisms. This implies that mineralocorticoids, including aldosterone, have great potential and value for the diagnosis and treatment of DR. Because early studies did not focus on the intrinsic association between mineralocorticoids and DR, targeted research is still in its infancy and there are still many obstacles to its application in the clinical setting. Recent studies have improved the understanding of the effects of aldosterone on DR, and we review them with the aim of exploring possible mechanisms for the treatment and prevention of DR. |
| first_indexed | 2024-04-09T18:40:22Z |
| format | Article |
| id | doaj.art-2508b2a9fc414fc9b680a6b0b91cae67 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T18:40:22Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2508b2a9fc414fc9b680a6b0b91cae672023-04-11T05:39:39ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11637871163787The role of aldosterone in the pathogenesis of diabetic retinopathyKangcheng Liu0Hua Zou1Huimin Fan2Hanying Hu3Yanhua Cheng4Jingying Liu5Xiaojian Wu6Bolin Chen7Zhipeng You8Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, ChinaHunan Key Laboratory of Ophthalmology, Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, ChinaJiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of Nanchang University, Nanchang, ChinaAldosterone, as a mineralocorticoid of adrenal origin, has effects that are not limited to the urinary tract. As an important regulator in Vasoactive hormone pathways, aldosterone may play an effect in the pathogenesis of diabetic retinopathy (DR) through the regulation of oxidative stress, vascular regulation, and inflammatory mechanisms. This implies that mineralocorticoids, including aldosterone, have great potential and value for the diagnosis and treatment of DR. Because early studies did not focus on the intrinsic association between mineralocorticoids and DR, targeted research is still in its infancy and there are still many obstacles to its application in the clinical setting. Recent studies have improved the understanding of the effects of aldosterone on DR, and we review them with the aim of exploring possible mechanisms for the treatment and prevention of DR.https://www.frontiersin.org/articles/10.3389/fendo.2023.1163787/fullaldosteronemineralocorticoiddiabetic retinopathyinflammationangiogenesis |
| spellingShingle | Kangcheng Liu Hua Zou Huimin Fan Hanying Hu Yanhua Cheng Jingying Liu Xiaojian Wu Bolin Chen Zhipeng You The role of aldosterone in the pathogenesis of diabetic retinopathy Frontiers in Endocrinology aldosterone mineralocorticoid diabetic retinopathy inflammation angiogenesis |
| title | The role of aldosterone in the pathogenesis of diabetic retinopathy |
| title_full | The role of aldosterone in the pathogenesis of diabetic retinopathy |
| title_fullStr | The role of aldosterone in the pathogenesis of diabetic retinopathy |
| title_full_unstemmed | The role of aldosterone in the pathogenesis of diabetic retinopathy |
| title_short | The role of aldosterone in the pathogenesis of diabetic retinopathy |
| title_sort | role of aldosterone in the pathogenesis of diabetic retinopathy |
| topic | aldosterone mineralocorticoid diabetic retinopathy inflammation angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1163787/full |
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