Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key aspects of the actin cytoskeleton, but their role in proliferation and cancer initiation or progression is not known. Here, we provide evidence that ROCK1 and ROCK2 act redundantly to maintain actomyosin contractility...

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Bibliographic Details
Main Authors: Sandra Kümper, Faraz K Mardakheh, Afshan McCarthy, Maggie Yeo, Gordon W Stamp, Angela Paul, Jonathan Worboys, Amine Sadok, Claus Jørgensen, Sabrina Guichard, Christopher J Marshall
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
rho kinase
ROCK
cellular senescence
cell proliferation
actomyosin contractility
actin cytoskeleton
Online Access:https://elifesciences.org/articles/12203

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