Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy
Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients. Benefits include not...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1675 |
| _version_ | 1797566146297200640 |
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| author | Peter M. Anderson Rajesh V. Lalla |
| author_facet | Peter M. Anderson Rajesh V. Lalla |
| author_sort | Peter M. Anderson |
| collection | DOAJ |
| description | Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients. Benefits include not only better nutrition, but also decreased mucosal damage (mucositis, stomatitis, pharyngitis, esophagitis, and enteritis). Glutamine supplementation in a high protein diet (10 grams/day) + disaccharides, such as sucrose and/or trehalose, is a combination that increases glutamine uptake by mucosal cells. This increased topical effect can reduce painful mucosal symptoms and ulceration associated with chemotherapy and radiation in the head and neck region, esophagus, stomach and small intestine. Topical and oral glutamine seem to be the preferred routes for this amino acid to promote mucosal healing during and after cancer treatment. |
| first_indexed | 2024-03-10T19:22:32Z |
| format | Article |
| id | doaj.art-2509b99d65d94e43b9b7a11a497952ef |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:22:32Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-2509b99d65d94e43b9b7a11a497952ef2023-11-20T02:50:56ZengMDPI AGNutrients2072-66432020-06-01126167510.3390/nu12061675Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer TherapyPeter M. Anderson0Rajesh V. Lalla1Cleveland Clinic Pediatric Hematology/Oncology and Bone Marrow Transplant, Pediatric Institute and Taussig Cancer Institute, Cleveland, OH 44195, USAUConn Health, School of Dental Medicine, Farmington, CT 06030 USAGlutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients. Benefits include not only better nutrition, but also decreased mucosal damage (mucositis, stomatitis, pharyngitis, esophagitis, and enteritis). Glutamine supplementation in a high protein diet (10 grams/day) + disaccharides, such as sucrose and/or trehalose, is a combination that increases glutamine uptake by mucosal cells. This increased topical effect can reduce painful mucosal symptoms and ulceration associated with chemotherapy and radiation in the head and neck region, esophagus, stomach and small intestine. Topical and oral glutamine seem to be the preferred routes for this amino acid to promote mucosal healing during and after cancer treatment. https://www.mdpi.com/2072-6643/12/6/1675glutaminetrehalosemucositisradiation injurychemotherapy associated malnutritionglutathione |
| spellingShingle | Peter M. Anderson Rajesh V. Lalla Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy Nutrients glutamine trehalose mucositis radiation injury chemotherapy associated malnutrition glutathione |
| title | Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy |
| title_full | Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy |
| title_fullStr | Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy |
| title_full_unstemmed | Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy |
| title_short | Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy |
| title_sort | glutamine for amelioration of radiation and chemotherapy associated mucositis during cancer therapy |
| topic | glutamine trehalose mucositis radiation injury chemotherapy associated malnutrition glutathione |
| url | https://www.mdpi.com/2072-6643/12/6/1675 |
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