High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux
Abstract Background Globus pharyngeus is common and has a low cure rate. Its etiology is complex and reported to be associated with laryngopharyngeal reflux (LPR). However, some patients with globus do not exhibit any reflux symptoms or respond to proton pump inhibitors (PPIs) treatments. The purpos...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-10-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-017-0666-x |
| _version_ | 1818528897162018816 |
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| author | Heyan Ding Zhijun Duan Dong Yang Zhifeng Zhang Lixia Wang Xiaoyu Sun Yiwen Yao Xue Lin Hang Yang Shan Wang Jiande D. Z. Chen |
| author_facet | Heyan Ding Zhijun Duan Dong Yang Zhifeng Zhang Lixia Wang Xiaoyu Sun Yiwen Yao Xue Lin Hang Yang Shan Wang Jiande D. Z. Chen |
| author_sort | Heyan Ding |
| collection | DOAJ |
| description | Abstract Background Globus pharyngeus is common and has a low cure rate. Its etiology is complex and reported to be associated with laryngopharyngeal reflux (LPR). However, some patients with globus do not exhibit any reflux symptoms or respond to proton pump inhibitors (PPIs) treatments. The purpose of this study was to clarify the related risk factors of these patients with a final objective of improving the curative effect. Methods Forty two patients afflicted with globus pharyngeus (G group) and 38 patients without globus pharyngeus (NG group) were included in this study. According to the laryngopharyngeal Reflux Symptom Index and the response to PPIs treatments, the patients were further divided into reflux groups (G-R, NG-R) and non-reflux groups (G-NR, NG-NR). High Resolution Manometry (HRM) was performed to assess esophageal motility. Questionnaires, including categories such as life exposure factors, were conducted. Results a) The average resting and residual pressures of the upper esophageal sphincter (UES) in the G-NR group was higher than in the NG-NR and NG-R groups (P < 0.05). b) The average resting and residual pressures of the lower esophageal sphincter showed no differences between the G-NR group and the NG-NR group (P > 0.05). c) The esophageal distal contractile integral score of the G-NR group was not different from the NG-NR group (P > 0.05). d) Compared to the NG-NR group, the G-NR group showed higher incidence of stress, smoking, drinking, high salt and anxiety (P < 0.05). Conclusions Globus pharyngeus without LPR may occur due to high UES pressure. Stress, smoking, alcoholic drinking, high salt and anxiety may be its risk factors. |
| first_indexed | 2024-12-11T06:56:01Z |
| format | Article |
| id | doaj.art-250c333eb2f54acf88f75809a44826f9 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-11T06:56:01Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-250c333eb2f54acf88f75809a44826f92022-12-22T01:16:46ZengBMCBMC Gastroenterology1471-230X2017-10-011711810.1186/s12876-017-0666-xHigh-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal refluxHeyan Ding0Zhijun Duan1Dong Yang2Zhifeng Zhang3Lixia Wang4Xiaoyu Sun5Yiwen Yao6Xue Lin7Hang Yang8Shan Wang9Jiande D. Z. Chen10Neurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityNeurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityNeurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityNeurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityNeurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityNeurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityOtolaryngology Department, First Affiliated Hospital of Dalian Medical UniversityNeurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityNeurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityNeurogastroenterology and Motility Center of China-US Cooperation, Second Gastroenterology Department, First Affiliated Hospital of Dalian Medical UniversityDivision of Gastroenterology and Hepatology, Johns Hopkins MedicineAbstract Background Globus pharyngeus is common and has a low cure rate. Its etiology is complex and reported to be associated with laryngopharyngeal reflux (LPR). However, some patients with globus do not exhibit any reflux symptoms or respond to proton pump inhibitors (PPIs) treatments. The purpose of this study was to clarify the related risk factors of these patients with a final objective of improving the curative effect. Methods Forty two patients afflicted with globus pharyngeus (G group) and 38 patients without globus pharyngeus (NG group) were included in this study. According to the laryngopharyngeal Reflux Symptom Index and the response to PPIs treatments, the patients were further divided into reflux groups (G-R, NG-R) and non-reflux groups (G-NR, NG-NR). High Resolution Manometry (HRM) was performed to assess esophageal motility. Questionnaires, including categories such as life exposure factors, were conducted. Results a) The average resting and residual pressures of the upper esophageal sphincter (UES) in the G-NR group was higher than in the NG-NR and NG-R groups (P < 0.05). b) The average resting and residual pressures of the lower esophageal sphincter showed no differences between the G-NR group and the NG-NR group (P > 0.05). c) The esophageal distal contractile integral score of the G-NR group was not different from the NG-NR group (P > 0.05). d) Compared to the NG-NR group, the G-NR group showed higher incidence of stress, smoking, drinking, high salt and anxiety (P < 0.05). Conclusions Globus pharyngeus without LPR may occur due to high UES pressure. Stress, smoking, alcoholic drinking, high salt and anxiety may be its risk factors.http://link.springer.com/article/10.1186/s12876-017-0666-xGlobus pharyngeusUpper esophageal sphincter (UES)Lower esophageal sphincter (LES)Distal esophageal contraction integral (DCI) |
| spellingShingle | Heyan Ding Zhijun Duan Dong Yang Zhifeng Zhang Lixia Wang Xiaoyu Sun Yiwen Yao Xue Lin Hang Yang Shan Wang Jiande D. Z. Chen High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux BMC Gastroenterology Globus pharyngeus Upper esophageal sphincter (UES) Lower esophageal sphincter (LES) Distal esophageal contraction integral (DCI) |
| title | High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux |
| title_full | High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux |
| title_fullStr | High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux |
| title_full_unstemmed | High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux |
| title_short | High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux |
| title_sort | high resolution manometry in patients with and without globus pharyngeus and or symptoms of laryngopharyngeal reflux |
| topic | Globus pharyngeus Upper esophageal sphincter (UES) Lower esophageal sphincter (LES) Distal esophageal contraction integral (DCI) |
| url | http://link.springer.com/article/10.1186/s12876-017-0666-x |
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