Induction of Apoptotic Temperature in Photothermal Therapy under Various Heating Conditions in Multi-Layered Skin Structure
Recently, photothermal therapy has attracted attention as an alternative treatment to conventional surgical techniques because it does not lead to bleeding and patients quickly recover after treatment compared to incisional surgery. Photothermal therapy induces tumor cell death through an increase i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/20/11091 |
| _version_ | 1797514361758023680 |
|---|---|
| author | Donghyuk Kim Hyunjung Kim |
| author_facet | Donghyuk Kim Hyunjung Kim |
| author_sort | Donghyuk Kim |
| collection | DOAJ |
| description | Recently, photothermal therapy has attracted attention as an alternative treatment to conventional surgical techniques because it does not lead to bleeding and patients quickly recover after treatment compared to incisional surgery. Photothermal therapy induces tumor cell death through an increase in the temperature using the photothermal effect, which converts light energy into thermal energy. This study was conducted to perform numerical analysis based on heat transfer to induce apoptosis of tumor tissue under various heating conditions in photothermal therapy. The Monte Carlo method was applied to evaluate a multi-layered skin structure containing squamous cell carcinoma. Tissue-equivalent phantom experiments verified the numerical model. Based on the effective apoptosis retention ratio, the numerical analysis results showed the quantitative correlation for the laser intensity, volume fraction of gold nanorods injected into the tumor, and cooling time. This study reveals optimal conditions for maximizing apoptosis within tumor tissue while minimizing thermal damage to surrounding tissues under various heating conditions. This approach may be useful as a standard treatment when performing photothermal therapy. |
| first_indexed | 2024-03-10T06:30:32Z |
| format | Article |
| id | doaj.art-250d44242bfc42d8bfadbd91eca8de10 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:30:32Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-250d44242bfc42d8bfadbd91eca8de102023-11-22T18:33:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122201109110.3390/ijms222011091Induction of Apoptotic Temperature in Photothermal Therapy under Various Heating Conditions in Multi-Layered Skin StructureDonghyuk Kim0Hyunjung Kim1Department of Mechanical Engineering, Ajou University, Suwon 16499, Gyeonggi-do, KoreaDepartment of Mechanical Engineering, Ajou University, Suwon 16499, Gyeonggi-do, KoreaRecently, photothermal therapy has attracted attention as an alternative treatment to conventional surgical techniques because it does not lead to bleeding and patients quickly recover after treatment compared to incisional surgery. Photothermal therapy induces tumor cell death through an increase in the temperature using the photothermal effect, which converts light energy into thermal energy. This study was conducted to perform numerical analysis based on heat transfer to induce apoptosis of tumor tissue under various heating conditions in photothermal therapy. The Monte Carlo method was applied to evaluate a multi-layered skin structure containing squamous cell carcinoma. Tissue-equivalent phantom experiments verified the numerical model. Based on the effective apoptosis retention ratio, the numerical analysis results showed the quantitative correlation for the laser intensity, volume fraction of gold nanorods injected into the tumor, and cooling time. This study reveals optimal conditions for maximizing apoptosis within tumor tissue while minimizing thermal damage to surrounding tissues under various heating conditions. This approach may be useful as a standard treatment when performing photothermal therapy.https://www.mdpi.com/1422-0067/22/20/11091apoptosisheat transferphotothermal therapysquamous cell carcinomathermal damage |
| spellingShingle | Donghyuk Kim Hyunjung Kim Induction of Apoptotic Temperature in Photothermal Therapy under Various Heating Conditions in Multi-Layered Skin Structure International Journal of Molecular Sciences apoptosis heat transfer photothermal therapy squamous cell carcinoma thermal damage |
| title | Induction of Apoptotic Temperature in Photothermal Therapy under Various Heating Conditions in Multi-Layered Skin Structure |
| title_full | Induction of Apoptotic Temperature in Photothermal Therapy under Various Heating Conditions in Multi-Layered Skin Structure |
| title_fullStr | Induction of Apoptotic Temperature in Photothermal Therapy under Various Heating Conditions in Multi-Layered Skin Structure |
| title_full_unstemmed | Induction of Apoptotic Temperature in Photothermal Therapy under Various Heating Conditions in Multi-Layered Skin Structure |
| title_short | Induction of Apoptotic Temperature in Photothermal Therapy under Various Heating Conditions in Multi-Layered Skin Structure |
| title_sort | induction of apoptotic temperature in photothermal therapy under various heating conditions in multi layered skin structure |
| topic | apoptosis heat transfer photothermal therapy squamous cell carcinoma thermal damage |
| url | https://www.mdpi.com/1422-0067/22/20/11091 |
| work_keys_str_mv | AT donghyukkim inductionofapoptotictemperatureinphotothermaltherapyundervariousheatingconditionsinmultilayeredskinstructure AT hyunjungkim inductionofapoptotictemperatureinphotothermaltherapyundervariousheatingconditionsinmultilayeredskinstructure |