Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-Analysis
Background and Aim: The present study was conducted to investigate the effects of granulocyte colony-stimulating factor (G-CSF) after acute spinal cord injury on increasing a grade of improvement entitled American spinal cord injury association impairment scale (AIS) as an individual participant...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Guilan University of Medical Sciences
2022-11-01
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| Series: | Iranian Journal of Neurosurgery |
| Subjects: | |
| Online Access: | https://irjns.org/article-1-322-en.pdf |
| _version_ | 1811220706078228480 |
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| author | Seyyed Amir Yasin Ahmadi Mohammad Javad Nourmohammadi Ahmed Sayahi Babak Alijani Shahrokh Yousefzadeh-Chabok Jafar Rezaian |
| author_facet | Seyyed Amir Yasin Ahmadi Mohammad Javad Nourmohammadi Ahmed Sayahi Babak Alijani Shahrokh Yousefzadeh-Chabok Jafar Rezaian |
| author_sort | Seyyed Amir Yasin Ahmadi |
| collection | DOAJ |
| description | Background and Aim: The present study was conducted to investigate the effects of granulocyte
colony-stimulating factor (G-CSF) after acute spinal cord injury on increasing a grade of improvement
entitled American spinal cord injury association impairment scale (AIS) as an individual participant
data (IPD) meta-regression analysis of clinical trials.
Methods and Materials/Patients: According to our search strategy, four studies were selected.
Multilevel ordered logistic regression modeling was used to predict AIS grade with G-CSF
administration and time variable (first day and a 3-month follow-up). The IDs of the studies as well
as the time series variable were imported to the random part of the model. Odds ratio (OR) and
95% confidence interval (CI) were reported.
Results: A total of 277 samples were studied. A fixed effect model was performed at first.
Accordingly, using G-CSF was associated with increased AIS grade (lower impairment) (OR=1.503,
95% CI=1.110-2.035) adjusted with time series (OR=1.868, 95% CI=1.378-2.532). In the mixed
effect model, G-CSF was again associated with increased AIS grade (OR=1.780, 95% CI=1.301-
2.436) adjusted with time series (OR=2.152, 95% CI=1.406-3.294).
Conclusion: The present meta-analysis showed the protective effect of GCS-F observed as an
improvement in AIS grade. This protecting effect was further after adjusting the random effects
of time series and individual studies. Although multilevel modeling could reduce our limitations,
it should be regarded that the number of trials was not enough to establish strong conclusions. |
| first_indexed | 2024-04-12T07:47:26Z |
| format | Article |
| id | doaj.art-250db674f3ef4e02bb1a2e69648439e5 |
| institution | Directory Open Access Journal |
| issn | 2423-6497 2423-6829 |
| language | English |
| last_indexed | 2024-04-12T07:47:26Z |
| publishDate | 2022-11-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neurosurgery |
| spelling | doaj.art-250db674f3ef4e02bb1a2e69648439e52022-12-22T03:41:41ZengGuilan University of Medical SciencesIranian Journal of Neurosurgery2423-64972423-68292022-11-018010.32598/irjns.8.15Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-AnalysisSeyyed Amir Yasin AhmadiMohammad Javad NourmohammadiAhmed SayahiBabak Alijani Shahrokh Yousefzadeh-ChabokJafar Rezaian Background and Aim: The present study was conducted to investigate the effects of granulocyte colony-stimulating factor (G-CSF) after acute spinal cord injury on increasing a grade of improvement entitled American spinal cord injury association impairment scale (AIS) as an individual participant data (IPD) meta-regression analysis of clinical trials. Methods and Materials/Patients: According to our search strategy, four studies were selected. Multilevel ordered logistic regression modeling was used to predict AIS grade with G-CSF administration and time variable (first day and a 3-month follow-up). The IDs of the studies as well as the time series variable were imported to the random part of the model. Odds ratio (OR) and 95% confidence interval (CI) were reported. Results: A total of 277 samples were studied. A fixed effect model was performed at first. Accordingly, using G-CSF was associated with increased AIS grade (lower impairment) (OR=1.503, 95% CI=1.110-2.035) adjusted with time series (OR=1.868, 95% CI=1.378-2.532). In the mixed effect model, G-CSF was again associated with increased AIS grade (OR=1.780, 95% CI=1.301- 2.436) adjusted with time series (OR=2.152, 95% CI=1.406-3.294). Conclusion: The present meta-analysis showed the protective effect of GCS-F observed as an improvement in AIS grade. This protecting effect was further after adjusting the random effects of time series and individual studies. Although multilevel modeling could reduce our limitations, it should be regarded that the number of trials was not enough to establish strong conclusions.https://irjns.org/article-1-322-en.pdfspinal cord injurymethylprednisolonemeta-analysismultilevel analysisstatistical modelsevidence-based medicine |
| spellingShingle | Seyyed Amir Yasin Ahmadi Mohammad Javad Nourmohammadi Ahmed Sayahi Babak Alijani Shahrokh Yousefzadeh-Chabok Jafar Rezaian Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-Analysis Iranian Journal of Neurosurgery spinal cord injury methylprednisolone meta-analysis multilevel analysis statistical models evidence-based medicine |
| title | Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-Analysis |
| title_full | Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-Analysis |
| title_fullStr | Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-Analysis |
| title_full_unstemmed | Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-Analysis |
| title_short | Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-Analysis |
| title_sort | effect of granulocyte colony stimulating factor g csf on improving impairment scale after acute spinal cord injury an individual participant data meta analysis |
| topic | spinal cord injury methylprednisolone meta-analysis multilevel analysis statistical models evidence-based medicine |
| url | https://irjns.org/article-1-322-en.pdf |
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