Conjunctival cytology in glaucomatous patients using long-term topical therapy
<b>Background:</b> Long-term use of antiglaucoma drugs induces adverse changes on the conjunctival surface. <b> Aim:</b> To evaluate the cytological changes in the conjunctival scrape smears of patients receiving long-term antiglaucoma medication and their histopathological...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2008-01-01
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| Series: | Journal of Cytology |
| Subjects: | |
| Online Access: | http://www.jcytol.org/article.asp?issn=0970-9371;year=2008;volume=25;issue=2;spage=50;epage=54;aulast=Sherwani |
| _version_ | 1811275380356546560 |
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| author | Sherwani Rana Khan Roobina Pervez Mohd Tauheed Asma Ashraf H Jilani F |
| author_facet | Sherwani Rana Khan Roobina Pervez Mohd Tauheed Asma Ashraf H Jilani F |
| author_sort | Sherwani Rana |
| collection | DOAJ |
| description | <b>Background:</b> Long-term use of antiglaucoma drugs induces adverse changes on the conjunctival surface. <b> Aim:</b> To evaluate the cytological changes in the conjunctival scrape smears of patients receiving long-term antiglaucoma medication and their histopathological correlation. <b> Materials and Methods:</b> Conjunctival scrape smears were taken from the eyes of patients on long-term antiglaucoma therapy for over three months (<i>n</i> = 75), patients taking antiglaucoma medication for less than three months (<i>n</i> = 100) and from glaucomatous patients in whom trabeculectomy was done as a primary procedure. Inflammatory cell counts, fibroblasts, and the degree of metaplasia were then evaluated both cytologically and histologically. The <i>t</i>-test was used to determine the predictive values of these parameters for the surgical outcome of trabeculectomies. <b> Results:</b> Long-term use of antiglaucoma therapy leads to a higher stage of metaplasia with an increase in the number of fibroblasts, subepithelial collagen deposition, and inflammatory infiltrate within the substantia propria of the conjunctiva. <b> Conclusions:</b> Long-term antiglaucoma medications induce a significant degree of metaplasia in the conjunctival surface that adversely affects the outcome of filtration surgery. |
| first_indexed | 2024-04-12T23:36:59Z |
| format | Article |
| id | doaj.art-250e4b5969e0429ca23cabf74f1ceba1 |
| institution | Directory Open Access Journal |
| issn | 0970-9371 |
| language | English |
| last_indexed | 2024-04-12T23:36:59Z |
| publishDate | 2008-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cytology |
| spelling | doaj.art-250e4b5969e0429ca23cabf74f1ceba12022-12-22T03:12:06ZengWolters Kluwer Medknow PublicationsJournal of Cytology0970-93712008-01-012525054Conjunctival cytology in glaucomatous patients using long-term topical therapySherwani RanaKhan RoobinaPervez MohdTauheed AsmaAshraf HJilani F<b>Background:</b> Long-term use of antiglaucoma drugs induces adverse changes on the conjunctival surface. <b> Aim:</b> To evaluate the cytological changes in the conjunctival scrape smears of patients receiving long-term antiglaucoma medication and their histopathological correlation. <b> Materials and Methods:</b> Conjunctival scrape smears were taken from the eyes of patients on long-term antiglaucoma therapy for over three months (<i>n</i> = 75), patients taking antiglaucoma medication for less than three months (<i>n</i> = 100) and from glaucomatous patients in whom trabeculectomy was done as a primary procedure. Inflammatory cell counts, fibroblasts, and the degree of metaplasia were then evaluated both cytologically and histologically. The <i>t</i>-test was used to determine the predictive values of these parameters for the surgical outcome of trabeculectomies. <b> Results:</b> Long-term use of antiglaucoma therapy leads to a higher stage of metaplasia with an increase in the number of fibroblasts, subepithelial collagen deposition, and inflammatory infiltrate within the substantia propria of the conjunctiva. <b> Conclusions:</b> Long-term antiglaucoma medications induce a significant degree of metaplasia in the conjunctival surface that adversely affects the outcome of filtration surgery.http://www.jcytol.org/article.asp?issn=0970-9371;year=2008;volume=25;issue=2;spage=50;epage=54;aulast=SherwaniConjunctiva; glaucoma; metaplasia; surgery. |
| spellingShingle | Sherwani Rana Khan Roobina Pervez Mohd Tauheed Asma Ashraf H Jilani F Conjunctival cytology in glaucomatous patients using long-term topical therapy Journal of Cytology Conjunctiva; glaucoma; metaplasia; surgery. |
| title | Conjunctival cytology in glaucomatous patients using long-term topical therapy |
| title_full | Conjunctival cytology in glaucomatous patients using long-term topical therapy |
| title_fullStr | Conjunctival cytology in glaucomatous patients using long-term topical therapy |
| title_full_unstemmed | Conjunctival cytology in glaucomatous patients using long-term topical therapy |
| title_short | Conjunctival cytology in glaucomatous patients using long-term topical therapy |
| title_sort | conjunctival cytology in glaucomatous patients using long term topical therapy |
| topic | Conjunctiva; glaucoma; metaplasia; surgery. |
| url | http://www.jcytol.org/article.asp?issn=0970-9371;year=2008;volume=25;issue=2;spage=50;epage=54;aulast=Sherwani |
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