In Vitro Profiling of Commonly Used Post-transplant Immunosuppressants Reveals Distinct Impact on Antiviral T-cell Immunity Towards CMV

In Vitro Profiling of Commonly Used Post-transplant Immunosuppressants Reveals Distinct Impact on Antiviral T-cell Immunity Towards CMV

Infectious complications, including widespread human cytomegalovirus (CMV) disease, frequently occur after hematopoietic stem cell and solid organ transplantation due to immunosuppressive treatment causing impairment of T-cell immunity. Therefore, in-depth analysis of the impact of immunosuppressant...

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Bibliographic Details
Main Authors: Markus Benedikt Krueger, Agnes Bonifacius, Anna Christina Dragon, Maria Michela Santamorena, Björn Nashan, Richard Taubert, Ulrich Kalinke, Britta Maecker-Kolhoff, Rainer Blasczyk, Britta Eiz-Vesper
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Transplant International
Subjects:
CMV-specific T cells
immunosuppression
adoptive T-cell therapy
solid organ transplantation
hematopoietic stem cell transplantation
Online Access:https://www.frontierspartnerships.org/articles/10.3389/ti.2024.12720/full

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