New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin
Glycopolymers with mannose units were readily prepared by click chemistry of an azido mannopyranoside derivative and a poly(propargyl acrylate-co-N-vinyl pyrrolidone). These glycopolymers were used as polymer surfactants, in order to obtain glycosylated polycaprolactone nanoparticles. Optimum stabil...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2010-06-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.6.58 |
| _version_ | 1818733517796802560 |
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| author | Otman Otman Paul Boullanger Eric Drockenmuller Thierry Hamaide |
| author_facet | Otman Otman Paul Boullanger Eric Drockenmuller Thierry Hamaide |
| author_sort | Otman Otman |
| collection | DOAJ |
| description | Glycopolymers with mannose units were readily prepared by click chemistry of an azido mannopyranoside derivative and a poly(propargyl acrylate-co-N-vinyl pyrrolidone). These glycopolymers were used as polymer surfactants, in order to obtain glycosylated polycaprolactone nanoparticles. Optimum stabilization for long time storage was achieved by using a mixture of glycopolymers and the non-ionic triblock copolymer Pluronic® F-68. The mannose moieties are accessible at the surface of nanoparticles and available for molecular recognition by concanavalin A lectin. Interaction of mannose units with the lectin were evaluated by measuring the changes in nanoparticles size by dynamic light scattering in dilute media. |
| first_indexed | 2024-12-17T23:50:44Z |
| format | Article |
| id | doaj.art-2510b939e32547039e509370f839ef15 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-17T23:50:44Z |
| publishDate | 2010-06-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-2510b939e32547039e509370f839ef152022-12-21T21:28:13ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972010-06-01615810.3762/bjoc.6.581860-5397-6-58New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectinOtman Otman0Paul Boullanger1Eric Drockenmuller2Thierry Hamaide3Université de Lyon; Université Lyon 1; Ingénierie des Matériaux Polymères, (IMP UMR CNRS 5223). 15, boulevard Latarjet, Villeurbanne, F-69622, FranceUniversité de Lyon; Université Lyon 1; Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Chimie Organique 2 – Glycochimie, UMR CNRS 5246, CPE-Lyon. 43, boulevard du 11 Novembre 1918, Villeurbanne, F-69622, FranceUniversité de Lyon; Université Lyon 1; Ingénierie des Matériaux Polymères, (IMP UMR CNRS 5223). 15, boulevard Latarjet, Villeurbanne, F-69622, FranceUniversité de Lyon; Université Lyon 1; Ingénierie des Matériaux Polymères, (IMP UMR CNRS 5223). 15, boulevard Latarjet, Villeurbanne, F-69622, FranceGlycopolymers with mannose units were readily prepared by click chemistry of an azido mannopyranoside derivative and a poly(propargyl acrylate-co-N-vinyl pyrrolidone). These glycopolymers were used as polymer surfactants, in order to obtain glycosylated polycaprolactone nanoparticles. Optimum stabilization for long time storage was achieved by using a mixture of glycopolymers and the non-ionic triblock copolymer Pluronic® F-68. The mannose moieties are accessible at the surface of nanoparticles and available for molecular recognition by concanavalin A lectin. Interaction of mannose units with the lectin were evaluated by measuring the changes in nanoparticles size by dynamic light scattering in dilute media.https://doi.org/10.3762/bjoc.6.58click chemistrycon A lectindynamic light scatteringglycopolymerpolymer nanoparticles |
| spellingShingle | Otman Otman Paul Boullanger Eric Drockenmuller Thierry Hamaide New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin Beilstein Journal of Organic Chemistry click chemistry con A lectin dynamic light scattering glycopolymer polymer nanoparticles |
| title | New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin |
| title_full | New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin |
| title_fullStr | New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin |
| title_full_unstemmed | New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin |
| title_short | New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin |
| title_sort | new amphiphilic glycopolymers by click functionalization of random copolymers application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin a lectin |
| topic | click chemistry con A lectin dynamic light scattering glycopolymer polymer nanoparticles |
| url | https://doi.org/10.3762/bjoc.6.58 |
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