Lumican in Carcinogenesis—Revisited
Carcinogenesis is a multifactorial process with the input and interactions of environmental, genetic, and metabolic factors. During cancer development, a significant remodeling of the extracellular matrix (ECM) is evident. Proteoglycans (PGs), such as lumican, are glycosylated proteins that particip...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/9/1319 |
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| author | Eirini-Maria Giatagana Aikaterini Berdiaki Aristidis Tsatsakis George N. Tzanakakis Dragana Nikitovic |
| author_facet | Eirini-Maria Giatagana Aikaterini Berdiaki Aristidis Tsatsakis George N. Tzanakakis Dragana Nikitovic |
| author_sort | Eirini-Maria Giatagana |
| collection | DOAJ |
| description | Carcinogenesis is a multifactorial process with the input and interactions of environmental, genetic, and metabolic factors. During cancer development, a significant remodeling of the extracellular matrix (ECM) is evident. Proteoglycans (PGs), such as lumican, are glycosylated proteins that participate in the formation of the ECM and are established biological mediators. Notably, lumican is involved in cellular processes associated with tumorigeneses, such as EMT (epithelial-to-mesenchymal transition), cellular proliferation, migration, invasion, and adhesion. Furthermore, lumican is expressed in various cancer tissues and is reported to have a positive or negative correlation with tumor progression. This review focuses on significant advances achieved regardingthe role of lumican in the tumor biology. Here, the effects of lumican on cancer cell growth, invasion, motility, and metastasis are discussed, as well as the repercussions on autophagy and apoptosis. Finally, in light of the available data, novel roles for lumican as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target are proposed. |
| first_indexed | 2024-03-10T07:51:59Z |
| format | Article |
| id | doaj.art-2511a828e57444eab9439b93aa6d4033 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T07:51:59Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-2511a828e57444eab9439b93aa6d40332023-11-22T12:10:51ZengMDPI AGBiomolecules2218-273X2021-09-01119131910.3390/biom11091319Lumican in Carcinogenesis—RevisitedEirini-Maria Giatagana0Aikaterini Berdiaki1Aristidis Tsatsakis2George N. Tzanakakis3Dragana Nikitovic4Laboratory of Histology-Embryology, Department of Morphology, School of Medicine, University of Crete, 71003 Heraklion, GreeceLaboratory of Histology-Embryology, Department of Morphology, School of Medicine, University of Crete, 71003 Heraklion, GreeceLaboratory of Toxicology, Department of Morphology, School of Medicine, University of Crete, 71003 Heraklion, GreeceLaboratory of Histology-Embryology, Department of Morphology, School of Medicine, University of Crete, 71003 Heraklion, GreeceLaboratory of Histology-Embryology, Department of Morphology, School of Medicine, University of Crete, 71003 Heraklion, GreeceCarcinogenesis is a multifactorial process with the input and interactions of environmental, genetic, and metabolic factors. During cancer development, a significant remodeling of the extracellular matrix (ECM) is evident. Proteoglycans (PGs), such as lumican, are glycosylated proteins that participate in the formation of the ECM and are established biological mediators. Notably, lumican is involved in cellular processes associated with tumorigeneses, such as EMT (epithelial-to-mesenchymal transition), cellular proliferation, migration, invasion, and adhesion. Furthermore, lumican is expressed in various cancer tissues and is reported to have a positive or negative correlation with tumor progression. This review focuses on significant advances achieved regardingthe role of lumican in the tumor biology. Here, the effects of lumican on cancer cell growth, invasion, motility, and metastasis are discussed, as well as the repercussions on autophagy and apoptosis. Finally, in light of the available data, novel roles for lumican as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target are proposed.https://www.mdpi.com/2218-273X/11/9/1319lumicancancerextracellular matrixproteoglycansmetastasiscancer cell growth |
| spellingShingle | Eirini-Maria Giatagana Aikaterini Berdiaki Aristidis Tsatsakis George N. Tzanakakis Dragana Nikitovic Lumican in Carcinogenesis—Revisited Biomolecules lumican cancer extracellular matrix proteoglycans metastasis cancer cell growth |
| title | Lumican in Carcinogenesis—Revisited |
| title_full | Lumican in Carcinogenesis—Revisited |
| title_fullStr | Lumican in Carcinogenesis—Revisited |
| title_full_unstemmed | Lumican in Carcinogenesis—Revisited |
| title_short | Lumican in Carcinogenesis—Revisited |
| title_sort | lumican in carcinogenesis revisited |
| topic | lumican cancer extracellular matrix proteoglycans metastasis cancer cell growth |
| url | https://www.mdpi.com/2218-273X/11/9/1319 |
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