Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum
Abstract Chronic kidney disease is commonly diagnosed in dogs, and clinical signs may be aggravated when infected agents are involved. In this case report, 33 dogs with chronic kidney disease were clinically evaluated and serologically tested for Leptospira spp., Ehrlichia canis, and Anaplasma phago...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Animal Diseases |
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| Online Access: | https://doi.org/10.1186/s44149-023-00103-w |
| _version_ | 1797630291307659264 |
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| author | Claire A. Vázquez-Manzanilla María F. Cárdenas-Marrufo Eduardo Gutiérrez-Blanco Matilde Jiménez-Coello Nelly R. Pech-Sosa Antonio Ortega-Pacheco |
| author_facet | Claire A. Vázquez-Manzanilla María F. Cárdenas-Marrufo Eduardo Gutiérrez-Blanco Matilde Jiménez-Coello Nelly R. Pech-Sosa Antonio Ortega-Pacheco |
| author_sort | Claire A. Vázquez-Manzanilla |
| collection | DOAJ |
| description | Abstract Chronic kidney disease is commonly diagnosed in dogs, and clinical signs may be aggravated when infected agents are involved. In this case report, 33 dogs with chronic kidney disease were clinically evaluated and serologically tested for Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum. The seroprevalence for Leptospira spp. was 39.4%. The most frequent serovars found were Pyrogenes, Canicola, Bratislava and Australis, with serological titers between 1:100 to 1:800. Clinical signs included fever, depression, decreased body condition, vomiting and hematuria. Significant laboratory findings were anemia, leukocytosis, thrombocytopenia, increased liver enzymes, urea and creatinine, hyperbilirubinemia and hyperphosphatemia. All leptospira seronegative dogs were positive for one or both monitored homoparasites (i.e., E. canis and A. phagocytophilum); only three leptospira seropositive dogs were positive for one or both hemoparasites. Findings also suggest that endemic hemoparasites of dogs should be monitored in dogs with a kidney condition for a better clinical picture of the patients and therapeutic approach. |
| first_indexed | 2024-03-11T11:06:15Z |
| format | Article |
| id | doaj.art-2512d16431234339af8ac4e2977a87b4 |
| institution | Directory Open Access Journal |
| issn | 2731-0442 |
| language | English |
| last_indexed | 2024-03-11T11:06:15Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Animal Diseases |
| spelling | doaj.art-2512d16431234339af8ac4e2977a87b42023-11-12T12:11:39ZengBMCAnimal Diseases2731-04422023-11-01311710.1186/s44149-023-00103-wClinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilumClaire A. Vázquez-Manzanilla0María F. Cárdenas-Marrufo1Eduardo Gutiérrez-Blanco2Matilde Jiménez-Coello3Nelly R. Pech-Sosa4Antonio Ortega-Pacheco5Departamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de YucatánUnidad Interinstitucional de Investigación Clínica y Epidemiológica, Facultad de Medicina, Universidad Autónoma de YucatánDepartamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de YucatánDepartamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de YucatánUnidad Interinstitucional de Investigación Clínica y Epidemiológica, Facultad de Medicina, Universidad Autónoma de YucatánDepartamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de YucatánAbstract Chronic kidney disease is commonly diagnosed in dogs, and clinical signs may be aggravated when infected agents are involved. In this case report, 33 dogs with chronic kidney disease were clinically evaluated and serologically tested for Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum. The seroprevalence for Leptospira spp. was 39.4%. The most frequent serovars found were Pyrogenes, Canicola, Bratislava and Australis, with serological titers between 1:100 to 1:800. Clinical signs included fever, depression, decreased body condition, vomiting and hematuria. Significant laboratory findings were anemia, leukocytosis, thrombocytopenia, increased liver enzymes, urea and creatinine, hyperbilirubinemia and hyperphosphatemia. All leptospira seronegative dogs were positive for one or both monitored homoparasites (i.e., E. canis and A. phagocytophilum); only three leptospira seropositive dogs were positive for one or both hemoparasites. Findings also suggest that endemic hemoparasites of dogs should be monitored in dogs with a kidney condition for a better clinical picture of the patients and therapeutic approach.https://doi.org/10.1186/s44149-023-00103-wAnaplasmaChronic kidney diseaseDogEhrlichiaLeptospira |
| spellingShingle | Claire A. Vázquez-Manzanilla María F. Cárdenas-Marrufo Eduardo Gutiérrez-Blanco Matilde Jiménez-Coello Nelly R. Pech-Sosa Antonio Ortega-Pacheco Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum Animal Diseases Anaplasma Chronic kidney disease Dog Ehrlichia Leptospira |
| title | Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum |
| title_full | Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum |
| title_fullStr | Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum |
| title_full_unstemmed | Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum |
| title_short | Clinical features of chronic kidney disease in dogs with the serological presence of Leptospira spp., Ehrlichia canis, and Anaplasma phagocytophilum |
| title_sort | clinical features of chronic kidney disease in dogs with the serological presence of leptospira spp ehrlichia canis and anaplasma phagocytophilum |
| topic | Anaplasma Chronic kidney disease Dog Ehrlichia Leptospira |
| url | https://doi.org/10.1186/s44149-023-00103-w |
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