Comparison of Oxidative Stress Markers and Serum Cortisol between Normal Labor and Selective Cesarean Section Born Neonates
Introduction: An imbalance between antioxidant and oxidantgenerating systems in newborns can cause oxidative damage. The effect of modes of delivery on oxidative stress in neonates is not fully investigated. Aim: This study was aimed to examine the effects of modes of delivery on oxidative stres...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7974/16935_CE(Ra1)_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: An imbalance between antioxidant and oxidantgenerating systems in newborns can cause oxidative damage.
The effect of modes of delivery on oxidative stress in neonates
is not fully investigated.
Aim: This study was aimed to examine the effects of modes of
delivery on oxidative stress markers and cortisol in newborns.
Materials and Methods: In this study 60 term neonates
{30 born via Normal Delivery (ND) and 30 born via elective
Caesarean Delivery (CS)} at birth were enrolled. Glutathione
Peroxidase (GPx), Catalase (CAT) and Superoxide Dismutase
(SOD) activities were determined in umbilical cord blood
in all neonates. Moreover serum cortisol, uric acid and Total
Antioxidant Capacity (TAC) were measured.
Results: GPx and SOD activities in cesarean born neonates
were significantly higher than those of control subjects (p<0.05).
TAC and CAT were not significantly different between the two
groups. Serum cortisol was lower in caesarean born subjects as
compared to normal born neonates. On the other hand uric acid
concentration was higher in caesarean born neonates.
Conclusion: The obtained data indicated that babies born
via caesarean section might be predisposed to pathological
conditions due to altered antioxidant levels. |
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| ISSN: | 2249-782X 0973-709X |