Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic
ABSTRACTBackground: The COVID-19 pandemic created a remarkable impact on healthcare providers (HCP) both physically and psychologically. Perceived psychological stress (PSS) influences the homeostatic equilibrium, involving activation of the sympathetic nervous system and hypothalamus pituitary adre...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Egyptian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/11101849.2021.1925442 |
| _version_ | 1797683725488619520 |
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| author | Hala M Demerdash Eman Omar Emad Arida |
| author_facet | Hala M Demerdash Eman Omar Emad Arida |
| author_sort | Hala M Demerdash |
| collection | DOAJ |
| description | ABSTRACTBackground: The COVID-19 pandemic created a remarkable impact on healthcare providers (HCP) both physically and psychologically. Perceived psychological stress (PSS) influences the homeostatic equilibrium, involving activation of the sympathetic nervous system and hypothalamus pituitary adrenal (HPA) axis. Copeptin, C-terminal portion of Vasopressin (AVP) precursor is stable; however, evidence about impact of PSS on copeptin levels is limited.Aim: The aim of this study was to estimate the influence of psychological stress on copeptin levels among HCP working in intensive care unit (ICU).Methods: A total of 70 HCP served in quarantine ICU participated in this prospective study; 35 physicians (28 males and 7 females) and 35 nurses (10 males and 25 females). A control group of 40 HCP matched age, BMI and specialty in non- quarantine hospitals. Fasting morning blood samples were withdrawn for determination of copeptin, cortisol, insulin at three points; pre-quarantine at ICU. Second point at end of first week and third point was two weeks’ post quarantine. A questionnaire was conducted to all participants to assess stress (PSS). Cortisol was determined by a chemiluminescence immunoassay while insulin and Copeptin were measured by ELISA.Results: Baseline plasma copeptin level pre-quarantine was significantly increased 15.76 ± 8.6 pmol/l (P = 0.001*) and was positively correlated with high stress PSS score mean 66.9 ± 18.3. Post-quarantine copeptin was markedly reduced 3.98 ± 1.28 pmol/l and mean PSS was 23.0 ± 7.95 (P = 0.001*). Also, there was positive correlation between plasma copeptin and PSS, systolic blood pressure and serum insulin. On the other hand, there was no correlation between copeptin and serum cortisol.Conclusion: Our finding suggested that copeptin may be used a potential biomarker for physiological strain during work in a stressful environment. |
| first_indexed | 2024-03-12T00:19:58Z |
| format | Article |
| id | doaj.art-25168d2b417a4241a3be76935ccf1505 |
| institution | Directory Open Access Journal |
| issn | 1110-1849 |
| language | English |
| last_indexed | 2024-03-12T00:19:58Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Egyptian Journal of Anaesthesia |
| spelling | doaj.art-25168d2b417a4241a3be76935ccf15052023-09-15T13:38:34ZengTaylor & Francis GroupEgyptian Journal of Anaesthesia1110-18492021-01-0137122723310.1080/11101849.2021.1925442Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemicHala M Demerdash0Eman Omar1Emad Arida2Department of Clinical Pathology, Alexandria University Hospitals, Alexandria University, Alexandria, EgyptAnaesthesia and Intensive Care, Faculty of Medicine, Alexandria University, Alexandria, EgyptAnaesthesia and Intensive Care, Faculty of Medicine, Alexandria University, Alexandria, EgyptABSTRACTBackground: The COVID-19 pandemic created a remarkable impact on healthcare providers (HCP) both physically and psychologically. Perceived psychological stress (PSS) influences the homeostatic equilibrium, involving activation of the sympathetic nervous system and hypothalamus pituitary adrenal (HPA) axis. Copeptin, C-terminal portion of Vasopressin (AVP) precursor is stable; however, evidence about impact of PSS on copeptin levels is limited.Aim: The aim of this study was to estimate the influence of psychological stress on copeptin levels among HCP working in intensive care unit (ICU).Methods: A total of 70 HCP served in quarantine ICU participated in this prospective study; 35 physicians (28 males and 7 females) and 35 nurses (10 males and 25 females). A control group of 40 HCP matched age, BMI and specialty in non- quarantine hospitals. Fasting morning blood samples were withdrawn for determination of copeptin, cortisol, insulin at three points; pre-quarantine at ICU. Second point at end of first week and third point was two weeks’ post quarantine. A questionnaire was conducted to all participants to assess stress (PSS). Cortisol was determined by a chemiluminescence immunoassay while insulin and Copeptin were measured by ELISA.Results: Baseline plasma copeptin level pre-quarantine was significantly increased 15.76 ± 8.6 pmol/l (P = 0.001*) and was positively correlated with high stress PSS score mean 66.9 ± 18.3. Post-quarantine copeptin was markedly reduced 3.98 ± 1.28 pmol/l and mean PSS was 23.0 ± 7.95 (P = 0.001*). Also, there was positive correlation between plasma copeptin and PSS, systolic blood pressure and serum insulin. On the other hand, there was no correlation between copeptin and serum cortisol.Conclusion: Our finding suggested that copeptin may be used a potential biomarker for physiological strain during work in a stressful environment.https://www.tandfonline.com/doi/10.1080/11101849.2021.1925442Psychological stresscortisolcopeptin |
| spellingShingle | Hala M Demerdash Eman Omar Emad Arida Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic Egyptian Journal of Anaesthesia Psychological stress cortisol copeptin |
| title | Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic |
| title_full | Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic |
| title_fullStr | Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic |
| title_full_unstemmed | Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic |
| title_short | Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic |
| title_sort | evaluation of copeptin and psychological stress among healthcare providers during covid 19 pandemic |
| topic | Psychological stress cortisol copeptin |
| url | https://www.tandfonline.com/doi/10.1080/11101849.2021.1925442 |
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