The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-<i>Zingiber offcinale</i> Polysaccharide
Most proteins given orally have low bioavailability and are easily eliminated by rapid metabolism in vivo. In order to immobilize the drug at the site of administration and delay its release, a natural, gentle release system was designed. In this study, a heteropolysaccharide (ZOP) was isolated from...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/11/18/2747 |
| _version_ | 1797488495092039680 |
|---|---|
| author | Yongshuai Jing Yameng Zhang Wenjing Cheng Mingsong Li Beibei Hu Yuguang Zheng Danshen Zhang Lanfang Wu |
| author_facet | Yongshuai Jing Yameng Zhang Wenjing Cheng Mingsong Li Beibei Hu Yuguang Zheng Danshen Zhang Lanfang Wu |
| author_sort | Yongshuai Jing |
| collection | DOAJ |
| description | Most proteins given orally have low bioavailability and are easily eliminated by rapid metabolism in vivo. In order to immobilize the drug at the site of administration and delay its release, a natural, gentle release system was designed. In this study, a heteropolysaccharide (ZOP) was isolated from <i>Zingiber officinale</i> using an ultrasonic assisted extraction method. ZOP Ara = 1.97: 1.15: 94.33: 1.48: 1.07. The ZOP/Chitosan (CS) composite hydrogel was synthesized using epichlorohydrin (ECH) as a cross-linking agent. The structure, morphology, and water-holding capacity of the composite hydrogel were characterized. The data showed that the addition of ZOP improved the hardness and water-holding capacity of the material. A swelling ratio test showed that the prepared hydrogel was sensitive to pH and ionic strength. In addition, the degradation rate of the hydrogel in a phosphate-buffered saline (PBS) solution with a pH value of 1.2 was higher than that in PBS with pH value of 7.4. Similarly, the release kinetics of Bovine serum albumin (BSA) showed higher release in an acidic system by the hydrogel composed of ZOP/CS. The hydrogel prepared by this study provided a good microenvironment for protein delivery. In summary, this composite polysaccharide hydrogel is a promising protein-drug-delivery material. |
| first_indexed | 2024-03-10T00:03:00Z |
| format | Article |
| id | doaj.art-25169dc4c4ce43bda58b4c4df00bb2f5 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T00:03:00Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-25169dc4c4ce43bda58b4c4df00bb2f52023-11-23T16:12:25ZengMDPI AGFoods2304-81582022-09-011118274710.3390/foods11182747The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-<i>Zingiber offcinale</i> PolysaccharideYongshuai Jing0Yameng Zhang1Wenjing Cheng2Mingsong Li3Beibei Hu4Yuguang Zheng5Danshen Zhang6Lanfang Wu7College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, ChinaCollege of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, ChinaCollege of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, ChinaCollege of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, ChinaCollege of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, ChinaCollege of Pharmacy, Hebei University of Chinese Medicine, 3 Xingyuan Road, Shijiazhuang 050200, ChinaCollege of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, ChinaCollege of Pharmacy, Hebei University of Chinese Medicine, 3 Xingyuan Road, Shijiazhuang 050200, ChinaMost proteins given orally have low bioavailability and are easily eliminated by rapid metabolism in vivo. In order to immobilize the drug at the site of administration and delay its release, a natural, gentle release system was designed. In this study, a heteropolysaccharide (ZOP) was isolated from <i>Zingiber officinale</i> using an ultrasonic assisted extraction method. ZOP Ara = 1.97: 1.15: 94.33: 1.48: 1.07. The ZOP/Chitosan (CS) composite hydrogel was synthesized using epichlorohydrin (ECH) as a cross-linking agent. The structure, morphology, and water-holding capacity of the composite hydrogel were characterized. The data showed that the addition of ZOP improved the hardness and water-holding capacity of the material. A swelling ratio test showed that the prepared hydrogel was sensitive to pH and ionic strength. In addition, the degradation rate of the hydrogel in a phosphate-buffered saline (PBS) solution with a pH value of 1.2 was higher than that in PBS with pH value of 7.4. Similarly, the release kinetics of Bovine serum albumin (BSA) showed higher release in an acidic system by the hydrogel composed of ZOP/CS. The hydrogel prepared by this study provided a good microenvironment for protein delivery. In summary, this composite polysaccharide hydrogel is a promising protein-drug-delivery material.https://www.mdpi.com/2304-8158/11/18/2747<i>Zingiber offtcinale</i>polysaccharidechitosanhydrogelsdrug releasedegradation |
| spellingShingle | Yongshuai Jing Yameng Zhang Wenjing Cheng Mingsong Li Beibei Hu Yuguang Zheng Danshen Zhang Lanfang Wu The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-<i>Zingiber offcinale</i> Polysaccharide Foods <i>Zingiber offtcinale</i> polysaccharide chitosan hydrogels drug release degradation |
| title | The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-<i>Zingiber offcinale</i> Polysaccharide |
| title_full | The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-<i>Zingiber offcinale</i> Polysaccharide |
| title_fullStr | The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-<i>Zingiber offcinale</i> Polysaccharide |
| title_full_unstemmed | The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-<i>Zingiber offcinale</i> Polysaccharide |
| title_short | The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-<i>Zingiber offcinale</i> Polysaccharide |
| title_sort | synthesis characterization and protein release properties of hydrogels composed of chitosan i zingiber offcinale i polysaccharide |
| topic | <i>Zingiber offtcinale</i> polysaccharide chitosan hydrogels drug release degradation |
| url | https://www.mdpi.com/2304-8158/11/18/2747 |
| work_keys_str_mv | AT yongshuaijing thesynthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT yamengzhang thesynthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT wenjingcheng thesynthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT mingsongli thesynthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT beibeihu thesynthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT yuguangzheng thesynthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT danshenzhang thesynthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT lanfangwu thesynthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT yongshuaijing synthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT yamengzhang synthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT wenjingcheng synthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT mingsongli synthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT beibeihu synthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT yuguangzheng synthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT danshenzhang synthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide AT lanfangwu synthesischaracterizationandproteinreleasepropertiesofhydrogelscomposedofchitosanizingiberoffcinaleipolysaccharide |