The Effects of Oxybutynin on Learning and Memory Functions In Passive Avoidance and Morris Water Maze Tests In Mice
Objective: Overactive bladder (OAB) constitutes the majority of childhood incontinence causes. Oxybutynin is an antimuscarinic agent frequently used for children in the treatment of OAB. This study aimed to investigate the effects of an antimuscarinic drug oxybutynin on learning and memory. Material...
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| Format: | Article |
| Language: | English |
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Sakarya University
2022-03-01
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| Series: | Sakarya Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2071361 |
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| author | Aykut Öztürk Oguz Mutlu Şeyma Nur Başarır Bozkurt Rümeysa Keleş Mehmet Emin Büyükokuroğlu Mehmet Hanifi Tanyeri Pelin Tanyeri |
| author_facet | Aykut Öztürk Oguz Mutlu Şeyma Nur Başarır Bozkurt Rümeysa Keleş Mehmet Emin Büyükokuroğlu Mehmet Hanifi Tanyeri Pelin Tanyeri |
| author_sort | Aykut Öztürk |
| collection | DOAJ |
| description | Objective: Overactive bladder (OAB) constitutes the majority of childhood incontinence causes. Oxybutynin is an antimuscarinic agent frequently used for children in the treatment of OAB. This study aimed to investigate the effects of an antimuscarinic drug oxybutynin on learning and memory.
Materials and Methods: We assessed the effects of oxybutynin on learning and memory functions using the Passive Avoidance (PA) and the Morris Water Maze (MWM) Test in mice.
Results: Oxybutynin treatment (1 mg/kg, 2 mg/kg, and 4 mg/kg) did not show a significant difference in the retention time on the second day compared to the control and oxybutynin (4 mg/kg) significantly prolonged the retention time in scopolamine-treated mice. In the MWM Test, oxybutynin (1 mg/kg, 2 mg/kg, and 4 mg/kg) has no effect on the time spent in the target quadrant. Scopolamine (0.6 mg/kg) alone significantly reduced time spent in the target quadrant, but oxybutynin (4 mg/kg) significantly prolonged time spent in the target quadrant in scopolamine-treated mice. Also, scopolamine significantly increased the mean distance to the escape platform, while oxybutynin (4 mg/kg) significantly decreased the mean distance to the escape platform in scopolamine-treated mice.
Conclusion: In our study, oxybutynin did not affect learning and memory, but it plays a role ameliorating the learning and memory deficits. The results of this study show that the use of oxybutynin in patients with OAB does not affect learning and memory. |
| first_indexed | 2024-03-08T12:45:07Z |
| format | Article |
| id | doaj.art-2516edf21dfb48d8a58f9c6be2f1ec22 |
| institution | Directory Open Access Journal |
| issn | 2146-409X |
| language | English |
| last_indexed | 2024-03-08T12:45:07Z |
| publishDate | 2022-03-01 |
| publisher | Sakarya University |
| record_format | Article |
| series | Sakarya Tıp Dergisi |
| spelling | doaj.art-2516edf21dfb48d8a58f9c6be2f1ec222024-01-21T07:40:07ZengSakarya UniversitySakarya Tıp Dergisi2146-409X2022-03-011219810610.31832/smj.102106728The Effects of Oxybutynin on Learning and Memory Functions In Passive Avoidance and Morris Water Maze Tests In MiceAykut Öztürk0Oguz Mutlu1Şeyma Nur Başarır Bozkurt2Rümeysa Keleş3Mehmet Emin Büyükokuroğlu4Mehmet Hanifi Tanyeri5Pelin Tanyeri6Recep Tayyip Erdogan Training and Research Hospital Department of PharmacologyKocaeli University, Faculty of Medicine. Department of PharmacologySAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACOLOGYSAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACOLOGYSAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACOLOGYYenikent Government Hospital, Department of UrologySAKARYA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACOLOGYObjective: Overactive bladder (OAB) constitutes the majority of childhood incontinence causes. Oxybutynin is an antimuscarinic agent frequently used for children in the treatment of OAB. This study aimed to investigate the effects of an antimuscarinic drug oxybutynin on learning and memory. Materials and Methods: We assessed the effects of oxybutynin on learning and memory functions using the Passive Avoidance (PA) and the Morris Water Maze (MWM) Test in mice. Results: Oxybutynin treatment (1 mg/kg, 2 mg/kg, and 4 mg/kg) did not show a significant difference in the retention time on the second day compared to the control and oxybutynin (4 mg/kg) significantly prolonged the retention time in scopolamine-treated mice. In the MWM Test, oxybutynin (1 mg/kg, 2 mg/kg, and 4 mg/kg) has no effect on the time spent in the target quadrant. Scopolamine (0.6 mg/kg) alone significantly reduced time spent in the target quadrant, but oxybutynin (4 mg/kg) significantly prolonged time spent in the target quadrant in scopolamine-treated mice. Also, scopolamine significantly increased the mean distance to the escape platform, while oxybutynin (4 mg/kg) significantly decreased the mean distance to the escape platform in scopolamine-treated mice. Conclusion: In our study, oxybutynin did not affect learning and memory, but it plays a role ameliorating the learning and memory deficits. The results of this study show that the use of oxybutynin in patients with OAB does not affect learning and memory.https://dergipark.org.tr/tr/download/article-file/2071361oksibutininskopolaminöğrenmebellekfareoxybutyninscopolaminelearningmemorymice |
| spellingShingle | Aykut Öztürk Oguz Mutlu Şeyma Nur Başarır Bozkurt Rümeysa Keleş Mehmet Emin Büyükokuroğlu Mehmet Hanifi Tanyeri Pelin Tanyeri The Effects of Oxybutynin on Learning and Memory Functions In Passive Avoidance and Morris Water Maze Tests In Mice Sakarya Tıp Dergisi oksibutinin skopolamin öğrenme bellek fare oxybutynin scopolamine learning memory mice |
| title | The Effects of Oxybutynin on Learning and Memory Functions In Passive Avoidance and Morris Water Maze Tests In Mice |
| title_full | The Effects of Oxybutynin on Learning and Memory Functions In Passive Avoidance and Morris Water Maze Tests In Mice |
| title_fullStr | The Effects of Oxybutynin on Learning and Memory Functions In Passive Avoidance and Morris Water Maze Tests In Mice |
| title_full_unstemmed | The Effects of Oxybutynin on Learning and Memory Functions In Passive Avoidance and Morris Water Maze Tests In Mice |
| title_short | The Effects of Oxybutynin on Learning and Memory Functions In Passive Avoidance and Morris Water Maze Tests In Mice |
| title_sort | effects of oxybutynin on learning and memory functions in passive avoidance and morris water maze tests in mice |
| topic | oksibutinin skopolamin öğrenme bellek fare oxybutynin scopolamine learning memory mice |
| url | https://dergipark.org.tr/tr/download/article-file/2071361 |
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