ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding

ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding

Condensin, which contains two structural maintenance of chromosome (SMC) subunits and three regulatory non-SMC subunits, is essential for many chromosomal functions, including mitotic chromosome condensation and segregation. The ATPase domain of the SMC subunit comprises two termini connected by a l...

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Bibliographic Details
Main Authors: Yuko Akai, Ryuta Kanai, Norihiko Nakazawa, Masahiro Ebe, Chikashi Toyoshima, Mitsuhiro Yanagida
Format: Article
Language:English
Published: The Royal Society 2014-01-01
Series:Open Biology
Subjects:
condensin
auto-phosphorylation
hinge opening
hinge interface
dna re-annealing
mass spectrometry
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140193

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