Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses

Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses

Abstract Both high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the complement and coagulation system, endothelial injury and multiple organ dysfunction syndrome in critical illnesses. Althou...

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Bibliographic Details
Main Authors: Yupei Li, Yu Chen, Tinghang Yang, Kaixi Chang, Ningyue Deng, Weifeng Zhao, Baihai Su
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Critical Care
Subjects:
High mobility group box-1
Histone
Extracorporeal blood purification
Inflammation
Sepsis
Critical illness
Online Access:https://doi.org/10.1186/s13054-023-04382-0

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