Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics

Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics

Disruption of protein:protein interactions (PPIs) that regulate the function of voltage-gated Na<sup>+</sup> (Nav) channels leads to neural circuitry aberrations that have been implicated in numerous channelopathies. One example of this pathophysiology is mediated by dysfunction of the P...

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Bibliographic Details
Main Authors: Nolan M. Dvorak, Paul A. Wadsworth, Pingyuan Wang, Haiying Chen, Jia Zhou, Fernanda Laezza
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
protein:protein interactions (PPIs)
voltage-gated Na<sup>+</sup> (Nav) channels
fibroblast growth factor 14 (FGF14)
peptidomimetics
molecular docking
neurotherapeutics
Online Access:https://www.mdpi.com/1420-3049/25/15/3365

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