A New Early Predictor of Fatal Outcome for COVID-19 in an Italian Emergency Department: The Modified Quick-SOFA
Background: Since 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing a rapidly spreading pandemic. The present study aims to compare a modified quick SOFA (MqSOFA) score with the NEWS-2 score to predict in-hospital mortality (IHM), 30-days mortality and recovery...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/4/806 |
| _version_ | 1797444693202567168 |
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| author | Matteo Guarino Benedetta Perna Francesca Remelli Francesca Cuoghi Alice Eleonora Cesaro Michele Domenico Spampinato Martina Maritati Carlo Contini Roberto De Giorgio |
| author_facet | Matteo Guarino Benedetta Perna Francesca Remelli Francesca Cuoghi Alice Eleonora Cesaro Michele Domenico Spampinato Martina Maritati Carlo Contini Roberto De Giorgio |
| author_sort | Matteo Guarino |
| collection | DOAJ |
| description | Background: Since 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing a rapidly spreading pandemic. The present study aims to compare a modified quick SOFA (MqSOFA) score with the NEWS-2 score to predict in-hospital mortality (IHM), 30-days mortality and recovery setting. Methods: All patients admitted from March to October 2020 to the Emergency Department of St. Anna Hospital, Ferrara, Italy with clinically suspected SARS-CoV-2 infection were retrospectively included in this single-centre study and evaluated with the MqSOFA and NEWS-2 scores. Statistical and logistic regression analyses were applied to our database. Results: A total of 3359 individual records were retrieved. Among them, 2716 patients were excluded because of a negative nasopharyngeal swab and 206 for lacking data; thus, 437 patients were eligible. The data showed that the MqSOFA and NEWS-2 scores equally predicted IHM (<i>p</i> < 0.001) and 30-days mortality (<i>p</i> < 0.001). Higher incidences of coronary artery disease, congestive heart failure, cerebrovascular accidents, dementia, chronic kidney disease and cancer were found in the deceased vs. survived group. Conclusions: In this study we confirmed that the MqSOFA score was non-inferior to the NEWS-2 score in predicting IHM and 30-days mortality. Furthermore, the MqSOFA score was easier to use than NEWS-2 and is more suitable for emergency settings. Neither the NEWS-2 nor the MqSOFA scores were able to predict the recovery setting. |
| first_indexed | 2024-03-09T13:16:11Z |
| format | Article |
| id | doaj.art-251ced15469b4f579f217eeb553eed1e |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T13:16:11Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-251ced15469b4f579f217eeb553eed1e2023-11-30T21:35:43ZengMDPI AGMicroorganisms2076-26072022-04-0110480610.3390/microorganisms10040806A New Early Predictor of Fatal Outcome for COVID-19 in an Italian Emergency Department: The Modified Quick-SOFAMatteo Guarino0Benedetta Perna1Francesca Remelli2Francesca Cuoghi3Alice Eleonora Cesaro4Michele Domenico Spampinato5Martina Maritati6Carlo Contini7Roberto De Giorgio8Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyDepartment of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyDepartment of Medical Sciences, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyDepartment of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyDepartment of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyDepartment of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyInfectious and Dermatology Diseases, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyInfectious and Dermatology Diseases, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyDepartment of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44121 Ferrara, ItalyBackground: Since 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing a rapidly spreading pandemic. The present study aims to compare a modified quick SOFA (MqSOFA) score with the NEWS-2 score to predict in-hospital mortality (IHM), 30-days mortality and recovery setting. Methods: All patients admitted from March to October 2020 to the Emergency Department of St. Anna Hospital, Ferrara, Italy with clinically suspected SARS-CoV-2 infection were retrospectively included in this single-centre study and evaluated with the MqSOFA and NEWS-2 scores. Statistical and logistic regression analyses were applied to our database. Results: A total of 3359 individual records were retrieved. Among them, 2716 patients were excluded because of a negative nasopharyngeal swab and 206 for lacking data; thus, 437 patients were eligible. The data showed that the MqSOFA and NEWS-2 scores equally predicted IHM (<i>p</i> < 0.001) and 30-days mortality (<i>p</i> < 0.001). Higher incidences of coronary artery disease, congestive heart failure, cerebrovascular accidents, dementia, chronic kidney disease and cancer were found in the deceased vs. survived group. Conclusions: In this study we confirmed that the MqSOFA score was non-inferior to the NEWS-2 score in predicting IHM and 30-days mortality. Furthermore, the MqSOFA score was easier to use than NEWS-2 and is more suitable for emergency settings. Neither the NEWS-2 nor the MqSOFA scores were able to predict the recovery setting.https://www.mdpi.com/2076-2607/10/4/806COVID-19in-hospital mortalityMqSOFAnCOV19NEWS2SARS-CoV-2 |
| spellingShingle | Matteo Guarino Benedetta Perna Francesca Remelli Francesca Cuoghi Alice Eleonora Cesaro Michele Domenico Spampinato Martina Maritati Carlo Contini Roberto De Giorgio A New Early Predictor of Fatal Outcome for COVID-19 in an Italian Emergency Department: The Modified Quick-SOFA Microorganisms COVID-19 in-hospital mortality MqSOFA nCOV19 NEWS2 SARS-CoV-2 |
| title | A New Early Predictor of Fatal Outcome for COVID-19 in an Italian Emergency Department: The Modified Quick-SOFA |
| title_full | A New Early Predictor of Fatal Outcome for COVID-19 in an Italian Emergency Department: The Modified Quick-SOFA |
| title_fullStr | A New Early Predictor of Fatal Outcome for COVID-19 in an Italian Emergency Department: The Modified Quick-SOFA |
| title_full_unstemmed | A New Early Predictor of Fatal Outcome for COVID-19 in an Italian Emergency Department: The Modified Quick-SOFA |
| title_short | A New Early Predictor of Fatal Outcome for COVID-19 in an Italian Emergency Department: The Modified Quick-SOFA |
| title_sort | new early predictor of fatal outcome for covid 19 in an italian emergency department the modified quick sofa |
| topic | COVID-19 in-hospital mortality MqSOFA nCOV19 NEWS2 SARS-CoV-2 |
| url | https://www.mdpi.com/2076-2607/10/4/806 |
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