Adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndrome
Background: Adiponectin and leptin play a major role in metabolic homeostasis. Adiponectin to Leptin ratio can be used as an indicator of insulin resistance and a marker of polycystic ovarian syndrome (PCOS). The study was planned to compare serum adiponectin, leptin, and adiponectin to leptin ratio...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
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| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=3;spage=239;epage=244;aulast=Mishra |
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| author | Pragya Mishra Pratima Mittal Anita Rani Rekha Bharti Varsha Agarwal Jyotsna Suri |
| author_facet | Pragya Mishra Pratima Mittal Anita Rani Rekha Bharti Varsha Agarwal Jyotsna Suri |
| author_sort | Pragya Mishra |
| collection | DOAJ |
| description | Background: Adiponectin and leptin play a major role in metabolic homeostasis. Adiponectin to Leptin ratio can be used as an indicator of insulin resistance and a marker of polycystic ovarian syndrome (PCOS). The study was planned to compare serum adiponectin, leptin, and adiponectin to leptin ratio in age and BMI matched women with and without PCOS and to find out the association of adiponectin to leptin ratio with Insulin resistance in these women. Methods: It was a cross-sectional study done in the Gynecology outpatient clinic in a tertiary care center. A total of 120 women, 60 with PCOS and 60 age and BMI matched women without PCOS, who presented in the clinic after the index cases were enrolled and tested for serum adiponectin, leptin, and insulin sensitivity. The main outcome measures were serum levels of adiponectin, leptin, adiponectin to leptin ratio, oral glucose tolerance test, serum insulin and HOMA-IR. Results: PCOS women had lower serum Adiponectin, higher serum Leptin level and lower Adiponectin to Leptin ratio compared to non PCOS women, 2.15 ± 3.07 ng/ml vs 10.7 ± 27.91 ng/ml, P < 0.0001; 24.25 ± 16.5 ng/ml vs 13.89 ± 11.19 ng/ml, P = 0.0003 and 0.15 ± 0.24 vs 3.03 ± 15.04, P < 0.0001, respectively. Plasma glucose 2 hours after 75 gm glucose and serum Insulin was significantly increased in PCOS women (108.78 ± 10.22 mg/dl vs 100.18 ± 4.89 mg/dl, P = 0.001 and 5.7 ± 9.53 μU/ml vs 3.02 ± 5.34 μU/ml, P = 0.02, respectively). The mean values of fasting plasma glucose and HOMA-IR were comparable in both groups, P = 0.145, P = 0.719, respectively. There was no significant association of A/L Ratio with BMI, plasma glucose 2 hours after 75 gm glucose, serum Insulin and HOMA-IR, in these women, r = -0.074, P = 0.5754; r = -0.203, P = 0.12; r = -0.018, P = 0.8915; and r = -0.041, P = 0.757, respectively. Conclusion: Adiponectin to leptin ratio is significantly reduced in women with PCOS but has no association with insulin resistance. |
| first_indexed | 2024-04-14T00:00:58Z |
| format | Article |
| id | doaj.art-25210709066a42138cde0bac2cd83bd0 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-04-14T00:00:58Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-25210709066a42138cde0bac2cd83bd02022-12-22T02:23:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102022-01-0126323924410.4103/ijem.ijem_137_22Adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndromePragya MishraPratima MittalAnita RaniRekha BhartiVarsha AgarwalJyotsna SuriBackground: Adiponectin and leptin play a major role in metabolic homeostasis. Adiponectin to Leptin ratio can be used as an indicator of insulin resistance and a marker of polycystic ovarian syndrome (PCOS). The study was planned to compare serum adiponectin, leptin, and adiponectin to leptin ratio in age and BMI matched women with and without PCOS and to find out the association of adiponectin to leptin ratio with Insulin resistance in these women. Methods: It was a cross-sectional study done in the Gynecology outpatient clinic in a tertiary care center. A total of 120 women, 60 with PCOS and 60 age and BMI matched women without PCOS, who presented in the clinic after the index cases were enrolled and tested for serum adiponectin, leptin, and insulin sensitivity. The main outcome measures were serum levels of adiponectin, leptin, adiponectin to leptin ratio, oral glucose tolerance test, serum insulin and HOMA-IR. Results: PCOS women had lower serum Adiponectin, higher serum Leptin level and lower Adiponectin to Leptin ratio compared to non PCOS women, 2.15 ± 3.07 ng/ml vs 10.7 ± 27.91 ng/ml, P < 0.0001; 24.25 ± 16.5 ng/ml vs 13.89 ± 11.19 ng/ml, P = 0.0003 and 0.15 ± 0.24 vs 3.03 ± 15.04, P < 0.0001, respectively. Plasma glucose 2 hours after 75 gm glucose and serum Insulin was significantly increased in PCOS women (108.78 ± 10.22 mg/dl vs 100.18 ± 4.89 mg/dl, P = 0.001 and 5.7 ± 9.53 μU/ml vs 3.02 ± 5.34 μU/ml, P = 0.02, respectively). The mean values of fasting plasma glucose and HOMA-IR were comparable in both groups, P = 0.145, P = 0.719, respectively. There was no significant association of A/L Ratio with BMI, plasma glucose 2 hours after 75 gm glucose, serum Insulin and HOMA-IR, in these women, r = -0.074, P = 0.5754; r = -0.203, P = 0.12; r = -0.018, P = 0.8915; and r = -0.041, P = 0.757, respectively. Conclusion: Adiponectin to leptin ratio is significantly reduced in women with PCOS but has no association with insulin resistance.http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=3;spage=239;epage=244;aulast=Mishraadiponectinadiponectin to leptin ratioinsulin resistanceleptinpcospolycystic ovarian syndrome |
| spellingShingle | Pragya Mishra Pratima Mittal Anita Rani Rekha Bharti Varsha Agarwal Jyotsna Suri Adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndrome Indian Journal of Endocrinology and Metabolism adiponectin adiponectin to leptin ratio insulin resistance leptin pcos polycystic ovarian syndrome |
| title | Adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndrome |
| title_full | Adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndrome |
| title_fullStr | Adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndrome |
| title_full_unstemmed | Adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndrome |
| title_short | Adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndrome |
| title_sort | adiponectin to leptin ratio and its association with insulin resistance in women with polycystic ovarian syndrome |
| topic | adiponectin adiponectin to leptin ratio insulin resistance leptin pcos polycystic ovarian syndrome |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2022;volume=26;issue=3;spage=239;epage=244;aulast=Mishra |
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