Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study
ObjectiveStatic regional homogeneity (ReHo) based on the resting-state functional magnetic resonance imaging (rs-fMRI) has been used to study intrinsic brain activity (IBA) in Alzheimer’s disease (AD). However, few studies have examined dynamic ReHo (dReHo) in AD. In this study, we used rs-fMRI and...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.951114/full |
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| author | Zhengluan Liao Zhengluan Liao Wangdi Sun Xiaozheng Liu Zhongwei Guo Dewang Mao Enyan Yu Yan Chen |
| author_facet | Zhengluan Liao Zhengluan Liao Wangdi Sun Xiaozheng Liu Zhongwei Guo Dewang Mao Enyan Yu Yan Chen |
| author_sort | Zhengluan Liao |
| collection | DOAJ |
| description | ObjectiveStatic regional homogeneity (ReHo) based on the resting-state functional magnetic resonance imaging (rs-fMRI) has been used to study intrinsic brain activity (IBA) in Alzheimer’s disease (AD). However, few studies have examined dynamic ReHo (dReHo) in AD. In this study, we used rs-fMRI and dReHo to investigate the alterations in dynamic IBA in patients with AD to uncover dynamic imaging markers of AD.MethodIn total, 111 patients with AD, 29 patients with mild cognitive impairment (MCI), and 73 healthy controls (HCs) were recruited for this study ultimately. After the rs-fMRI scan, we calculated the dReHo values using the sliding window method. ANOVA and post hoc two-sample t-tests were used to detect the differences among the three groups. We used the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) to evaluate the cognitive function of the subjects. The associations between the MMSE score, MoCA score, and dReHo were assessed by the Pearson correlation analysis.ResultsSignificant dReHo variability in the right middle frontal gyrus (MFG) and right posterior cingulate gyrus (PCG) was detected in the three groups through ANOVA. In post hoc analysis, the AD group exhibited significantly greater dReHo variability in the right MFG than the MCI group. Compared with the HC group, the AD group exhibited significantly increased dReHo variability in the right PCG. Furthermore, dReHo variability in the right PCG was significantly negatively correlated with the MMSE and MoCA scores of patients with AD.ConclusionDisrupted dynamic IBA in the DMN might be an important characteristic of AD and could be a potential biomarker for the diagnosis or prognosis of AD. |
| first_indexed | 2024-04-13T13:13:44Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-13T13:13:44Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-25218496ad9440c6b7834629cf2563f72022-12-22T02:45:32ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-08-011610.3389/fnhum.2022.951114951114Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI studyZhengluan Liao0Zhengluan Liao1Wangdi Sun2Xiaozheng Liu3Zhongwei Guo4Dewang Mao5Enyan Yu6Yan Chen7Department of Clinical Medicine, Medical College of Soochow University, Suzhou, ChinaDepartment of Geriatric VIP No. 3 (Department of Clinical Psychology), Rehabilitation Medicine Center, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaSecond Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaThe Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, ChinaTongde Hospital of Zhejiang Province, Hangzhou, ChinaDepartment of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaDepartment of Psychiatry, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, ChinaDepartment of Geriatric VIP No. 3 (Department of Clinical Psychology), Rehabilitation Medicine Center, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaObjectiveStatic regional homogeneity (ReHo) based on the resting-state functional magnetic resonance imaging (rs-fMRI) has been used to study intrinsic brain activity (IBA) in Alzheimer’s disease (AD). However, few studies have examined dynamic ReHo (dReHo) in AD. In this study, we used rs-fMRI and dReHo to investigate the alterations in dynamic IBA in patients with AD to uncover dynamic imaging markers of AD.MethodIn total, 111 patients with AD, 29 patients with mild cognitive impairment (MCI), and 73 healthy controls (HCs) were recruited for this study ultimately. After the rs-fMRI scan, we calculated the dReHo values using the sliding window method. ANOVA and post hoc two-sample t-tests were used to detect the differences among the three groups. We used the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) to evaluate the cognitive function of the subjects. The associations between the MMSE score, MoCA score, and dReHo were assessed by the Pearson correlation analysis.ResultsSignificant dReHo variability in the right middle frontal gyrus (MFG) and right posterior cingulate gyrus (PCG) was detected in the three groups through ANOVA. In post hoc analysis, the AD group exhibited significantly greater dReHo variability in the right MFG than the MCI group. Compared with the HC group, the AD group exhibited significantly increased dReHo variability in the right PCG. Furthermore, dReHo variability in the right PCG was significantly negatively correlated with the MMSE and MoCA scores of patients with AD.ConclusionDisrupted dynamic IBA in the DMN might be an important characteristic of AD and could be a potential biomarker for the diagnosis or prognosis of AD.https://www.frontiersin.org/articles/10.3389/fnhum.2022.951114/fullAlzheimer’s diseasemild cognitive impairmentresting-state functional magnetic resonance imagingregional homogeneitydefault mode network |
| spellingShingle | Zhengluan Liao Zhengluan Liao Wangdi Sun Xiaozheng Liu Zhongwei Guo Dewang Mao Enyan Yu Yan Chen Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study Frontiers in Human Neuroscience Alzheimer’s disease mild cognitive impairment resting-state functional magnetic resonance imaging regional homogeneity default mode network |
| title | Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study |
| title_full | Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study |
| title_fullStr | Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study |
| title_full_unstemmed | Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study |
| title_short | Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study |
| title_sort | altered dynamic intrinsic brain activity of the default mode network in alzheimer s disease a resting state fmri study |
| topic | Alzheimer’s disease mild cognitive impairment resting-state functional magnetic resonance imaging regional homogeneity default mode network |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.951114/full |
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