Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma Development
Oxidative stress (OS) is linked to hepatocellular carcinoma (HCC) progression. HCC may develop as a result of genetic changes, including oxidative injury to both nuclear and mitochondrial DNA. Signaling pathways regulated by OS, such as Wnt/β-catenin and Notch pathways, are vital regulators in devel...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-11-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811286 |
| _version_ | 1797400707857383424 |
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| author | Yuanyuan Li Yang Yu Lei Yang Rui Wang |
| author_facet | Yuanyuan Li Yang Yu Lei Yang Rui Wang |
| author_sort | Yuanyuan Li |
| collection | DOAJ |
| description | Oxidative stress (OS) is linked to hepatocellular carcinoma (HCC) progression. HCC may develop as a result of genetic changes, including oxidative injury to both nuclear and mitochondrial DNA. Signaling pathways regulated by OS, such as Wnt/β-catenin and Notch pathways, are vital regulators in developing HCC. OS-mediated activation of transcription factors, including nuclear factor-κB and p53, among others, is capable of regulating the redox state of HCC cells. OS also affects the tumor microenvironment, which, in turn, regulates HCC progression. In HCC, reactive oxygen species (ROS) can potentially enhance tumor cell proliferation, metastasis, and resistance to treatment. However, elevated ROS levels can cause cytotoxicity and trigger apoptosis in HCC cells. This review highlights and explores potential oxidative stress-related treatment targets in HCC, offering novel insights for clinical therapies. |
| first_indexed | 2024-03-09T01:59:24Z |
| format | Article |
| id | doaj.art-2522bc0595ea449db8a1a11ffd2c1a21 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-09T01:59:24Z |
| publishDate | 2023-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-2522bc0595ea449db8a1a11ffd2c1a212023-12-08T07:49:20ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-11-01281128610.31083/j.fbl2811286S2768-6701(23)00973-5Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma DevelopmentYuanyuan Li0Yang Yu1Lei Yang2Rui Wang3Department of Medical Oncology, Affiliated Tumor Hospital, Nantong University, 226300 Nantong, Jiangsu, ChinaDepartment of Medical Oncology, Affiliated Tumor Hospital, Nantong University, 226300 Nantong, Jiangsu, ChinaDepartment of Medical Oncology, Affiliated Tumor Hospital, Nantong University, 226300 Nantong, Jiangsu, ChinaDepartment of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, 210016 Nanjing, Jiangsu, ChinaOxidative stress (OS) is linked to hepatocellular carcinoma (HCC) progression. HCC may develop as a result of genetic changes, including oxidative injury to both nuclear and mitochondrial DNA. Signaling pathways regulated by OS, such as Wnt/β-catenin and Notch pathways, are vital regulators in developing HCC. OS-mediated activation of transcription factors, including nuclear factor-κB and p53, among others, is capable of regulating the redox state of HCC cells. OS also affects the tumor microenvironment, which, in turn, regulates HCC progression. In HCC, reactive oxygen species (ROS) can potentially enhance tumor cell proliferation, metastasis, and resistance to treatment. However, elevated ROS levels can cause cytotoxicity and trigger apoptosis in HCC cells. This review highlights and explores potential oxidative stress-related treatment targets in HCC, offering novel insights for clinical therapies.https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811286oxidative stresshccgenetic changessignaling pathwaystranscription factorstumor microenvironmenttreatment targets |
| spellingShingle | Yuanyuan Li Yang Yu Lei Yang Rui Wang Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma Development Frontiers in Bioscience-Landmark oxidative stress hcc genetic changes signaling pathways transcription factors tumor microenvironment treatment targets |
| title | Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma Development |
| title_full | Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma Development |
| title_fullStr | Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma Development |
| title_full_unstemmed | Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma Development |
| title_short | Insights into the Role of Oxidative Stress in Hepatocellular Carcinoma Development |
| title_sort | insights into the role of oxidative stress in hepatocellular carcinoma development |
| topic | oxidative stress hcc genetic changes signaling pathways transcription factors tumor microenvironment treatment targets |
| url | https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811286 |
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