H3K36 Trimethylation-Mediated Epigenetic Regulation is Activated by Bam and Promotes Germ Cell Differentiation During Early Oogenesis in Drosophila

H3K36 Trimethylation-Mediated Epigenetic Regulation is Activated by Bam and Promotes Germ Cell Differentiation During Early Oogenesis in Drosophila

Epigenetic silencing is critical for maintaining germline stem cells in Drosophila ovaries. However, it remains unclear how the differentiation factor, Bag-of-marbles (Bam), counteracts transcriptional silencing. We found that the trimethylation of lysine 36 on histone H3 (H3K36me3), a modification...

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Bibliographic Details
Main Authors: Masanori Mukai, Seiji Hira, Katsuhiro Nakamura, Shoichi Nakamura, Hiroshi Kimura, Masanao Sato, Satoru Kobayashi
Format: Article
Language:English
Published: The Company of Biologists 2015-01-01
Series:Biology Open
Subjects:
Drosophila
Germ cell
Differentiation factor
Histone modification
Transcriptional control
Online Access:http://bio.biologists.org/content/4/2/119

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