Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.
Bibliographic Details
| Main Authors: |
Jennifer C. Chan,
Christopher P. Morgan,
N. Adrian Leu,
Amol Shetty,
Yasmine M. Cisse,
Bridget M. Nugent,
Kathleen E. Morrison,
Eldin Jašarević,
Weiliang Huang,
Nickole Kanyuch,
Ali B. Rodgers,
Natarajan V. Bhanu,
Dara S. Berger,
Benjamin A. Garcia,
Seth Ament,
Maureen Kane,
C. Neill Epperson,
Tracy L. Bale |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-15305-w
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