The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study
Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases in adults that cause disability in patients. Different studies were conducted on more rapid diagnosis of the disease such as measuring serum or cerebrospinal fluid (CSF) contents. Objectives: The current study aimed at...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Guilan University of Medical Sciences
2017-10-01
|
| Series: | Caspian Journal of Neurological Sciences |
| Subjects: | |
| Online Access: | http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-88&slc_lang=en&sid=1 |
| _version_ | 1818382753033355264 |
|---|---|
| author | Masoud Etemadifar Mozhgan Ghadimi Keyvan Ghadimi Fereshteh Alsahebfosoul |
| author_facet | Masoud Etemadifar Mozhgan Ghadimi Keyvan Ghadimi Fereshteh Alsahebfosoul |
| author_sort | Masoud Etemadifar |
| collection | DOAJ |
| description | Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases in adults that cause disability in patients. Different studies were conducted on more rapid diagnosis of the disease such as measuring serum or cerebrospinal fluid (CSF) contents.
Objectives: The current study aimed at measuring amyloid β (Aβ) serum levels in patients with relapsing-remitting MS.
Materials and Methods: In the current case-control study, the serum levels of Aβ were measured in 48 patients with RRMS and 33 healthy controls using the enzyme-linked immunosorbent assay (ELISA) technique in Isfahan, Iran, from 2014 to 2016. Data analysis was conducted with SPSS.
Results: The mean serum level of Aβ in the case (patients with RRMS) and control groups were 192.75±125.65 and 128.11±85.20 pg/mL, respectively; so serum Aβ levels in the RRMS group was significantly higher than healthy controls (p=0.02). Also, there was a positive significant correlation between the serum Aβ levels and the expanded disability status scale (EDSS) (r=+0.85, p<0.0001).
Conclusions: Owing to the increase of serum Aβ level in patients with RRMS and its significant increase in severe MS cases (higher EDSS scores), so serum Aβ level can be considered as a marker for MS and its progression. |
| first_indexed | 2024-12-14T02:55:28Z |
| format | Article |
| id | doaj.art-2526b2813f814c1ab027eac82d747495 |
| institution | Directory Open Access Journal |
| issn | 2383-4307 2423-4818 |
| language | English |
| last_indexed | 2024-12-14T02:55:28Z |
| publishDate | 2017-10-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj.art-2526b2813f814c1ab027eac82d7474952022-12-21T23:19:37ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2383-43072423-48182017-10-01311214221The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control StudyMasoud Etemadifar0Mozhgan Ghadimi1Keyvan Ghadimi2Fereshteh Alsahebfosoul3 Iranian Multiple Sclerosis and Neuroimmunology Research Center, Isfahan, Iran School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Iranian Multiple Sclerosis and Neuroimmunology Research Center, Isfahan, Iran; keyvanghadimi@yahoo.com Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases in adults that cause disability in patients. Different studies were conducted on more rapid diagnosis of the disease such as measuring serum or cerebrospinal fluid (CSF) contents. Objectives: The current study aimed at measuring amyloid β (Aβ) serum levels in patients with relapsing-remitting MS. Materials and Methods: In the current case-control study, the serum levels of Aβ were measured in 48 patients with RRMS and 33 healthy controls using the enzyme-linked immunosorbent assay (ELISA) technique in Isfahan, Iran, from 2014 to 2016. Data analysis was conducted with SPSS. Results: The mean serum level of Aβ in the case (patients with RRMS) and control groups were 192.75±125.65 and 128.11±85.20 pg/mL, respectively; so serum Aβ levels in the RRMS group was significantly higher than healthy controls (p=0.02). Also, there was a positive significant correlation between the serum Aβ levels and the expanded disability status scale (EDSS) (r=+0.85, p<0.0001). Conclusions: Owing to the increase of serum Aβ level in patients with RRMS and its significant increase in severe MS cases (higher EDSS scores), so serum Aβ level can be considered as a marker for MS and its progression.http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-88&slc_lang=en&sid=1Multiple SclerosisAmyloidEnzyme-Linked Immunosorbent Assay |
| spellingShingle | Masoud Etemadifar Mozhgan Ghadimi Keyvan Ghadimi Fereshteh Alsahebfosoul The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study Caspian Journal of Neurological Sciences Multiple Sclerosis Amyloid Enzyme-Linked Immunosorbent Assay |
| title | The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study |
| title_full | The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study |
| title_fullStr | The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study |
| title_full_unstemmed | The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study |
| title_short | The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study |
| title_sort | serum amyloid β level in multiple sclerosis a case control study |
| topic | Multiple Sclerosis Amyloid Enzyme-Linked Immunosorbent Assay |
| url | http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-88&slc_lang=en&sid=1 |
| work_keys_str_mv | AT masoudetemadifar theserumamyloidblevelinmultiplesclerosisacasecontrolstudy AT mozhganghadimi theserumamyloidblevelinmultiplesclerosisacasecontrolstudy AT keyvanghadimi theserumamyloidblevelinmultiplesclerosisacasecontrolstudy AT fereshtehalsahebfosoul theserumamyloidblevelinmultiplesclerosisacasecontrolstudy AT masoudetemadifar serumamyloidblevelinmultiplesclerosisacasecontrolstudy AT mozhganghadimi serumamyloidblevelinmultiplesclerosisacasecontrolstudy AT keyvanghadimi serumamyloidblevelinmultiplesclerosisacasecontrolstudy AT fereshtehalsahebfosoul serumamyloidblevelinmultiplesclerosisacasecontrolstudy |