Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center
ObjectiveIndications for preimplantation genetic diagnosis (PGD)/preimplantation genetic screening (PGS) cycles and clinical outcomes were evaluated at CHA Gangnam Medical Center.MethodsThis is retrospective cohort study. All patients (n=336) who went through in vitro fertilization (IVF)-PGD/PGS cyc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2018-01-01
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| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://ogscience.org/upload/pdf/ogs-61-95.pdf |
| _version_ | 1818300356797399040 |
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| author | Se Yeon Won Hannah Kim Woo Sik Lee Ji Won Kim Sung Han Shim |
| author_facet | Se Yeon Won Hannah Kim Woo Sik Lee Ji Won Kim Sung Han Shim |
| author_sort | Se Yeon Won |
| collection | DOAJ |
| description | ObjectiveIndications for preimplantation genetic diagnosis (PGD)/preimplantation genetic screening (PGS) cycles and clinical outcomes were evaluated at CHA Gangnam Medical Center.MethodsThis is retrospective cohort study. All patients (n=336) who went through in vitro fertilization (IVF)-PGD/PGS cycles (n=486) between January 2014 and December 2015 were included in Fertility Center of CHA Gangnam Medical Center. Patients underwent IVF-PGD/PGS with 24-chromosome screening. Patients with euploid embryos had transfer of one or 2 embryos in a fresh cycle with any subsequent frozen embryo transfer (ET) cycle. Compared implantation, clinical pregnancy, ongoing pregnancy, and early abortion rates were the main outcome measures.ResultsThe most common indication for PGD/PGS was recurrent spontaneous abortion (n=160). The chromosome rearrangement cases (n=116) included 24 Robertsonian translocations, 60 reciprocal translocations, 3 inversions, 2 deletions, 4 additions, and 23 mosaicisms. PGS cases rather than the PGD cases showed higher implantation rates (26.4% vs. 20.3%), ongoing pregnancy rates (19.5% vs. 16.4%), and clinical pregnancy rates (28.6% vs. 23.3%). Implantation rates (30.3% vs. 23.7%), clinical pregnancy rates (39.2% vs. 25.2%), and ongoing pregnancy rates (25.7% vs. 17.5%) were significant higher in the blastocyst evaluation group than cleavage stage evaluation group.ConclusionThis was the largest study of PGD/PGS for 2 years at a single center in Korea. The pregnancy outcomes of PGD cases are slightly lower than PGS cases. It was confirmed again that success rate of PGD/PGS is higher if biopsy was done at blastocyst than cleavage stage. |
| first_indexed | 2024-12-13T05:05:49Z |
| format | Article |
| id | doaj.art-2526b7274566453794981edd944dc211 |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-12-13T05:05:49Z |
| publishDate | 2018-01-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-2526b7274566453794981edd944dc2112022-12-21T23:58:40ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802018-01-016119510110.5468/ogs.2018.61.1.95555Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single centerSe Yeon Won0Hannah Kim1Woo Sik Lee2Ji Won Kim3Sung Han Shim4Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, Seoul, .KoreaDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, .KoreaGenetics Laboratory, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, .KoreaObjectiveIndications for preimplantation genetic diagnosis (PGD)/preimplantation genetic screening (PGS) cycles and clinical outcomes were evaluated at CHA Gangnam Medical Center.MethodsThis is retrospective cohort study. All patients (n=336) who went through in vitro fertilization (IVF)-PGD/PGS cycles (n=486) between January 2014 and December 2015 were included in Fertility Center of CHA Gangnam Medical Center. Patients underwent IVF-PGD/PGS with 24-chromosome screening. Patients with euploid embryos had transfer of one or 2 embryos in a fresh cycle with any subsequent frozen embryo transfer (ET) cycle. Compared implantation, clinical pregnancy, ongoing pregnancy, and early abortion rates were the main outcome measures.ResultsThe most common indication for PGD/PGS was recurrent spontaneous abortion (n=160). The chromosome rearrangement cases (n=116) included 24 Robertsonian translocations, 60 reciprocal translocations, 3 inversions, 2 deletions, 4 additions, and 23 mosaicisms. PGS cases rather than the PGD cases showed higher implantation rates (26.4% vs. 20.3%), ongoing pregnancy rates (19.5% vs. 16.4%), and clinical pregnancy rates (28.6% vs. 23.3%). Implantation rates (30.3% vs. 23.7%), clinical pregnancy rates (39.2% vs. 25.2%), and ongoing pregnancy rates (25.7% vs. 17.5%) were significant higher in the blastocyst evaluation group than cleavage stage evaluation group.ConclusionThis was the largest study of PGD/PGS for 2 years at a single center in Korea. The pregnancy outcomes of PGD cases are slightly lower than PGS cases. It was confirmed again that success rate of PGD/PGS is higher if biopsy was done at blastocyst than cleavage stage.http://ogscience.org/upload/pdf/ogs-61-95.pdf fertilizationpreimplantation genetic diagnosis |
| spellingShingle | Se Yeon Won Hannah Kim Woo Sik Lee Ji Won Kim Sung Han Shim Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center Obstetrics & Gynecology Science fertilization preimplantation genetic diagnosis |
| title | Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center |
| title_full | Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center |
| title_fullStr | Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center |
| title_full_unstemmed | Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center |
| title_short | Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center |
| title_sort | pre implantation genetic diagnosis and pre implantation genetic screening two years experience at a single center |
| topic | fertilization preimplantation genetic diagnosis |
| url | http://ogscience.org/upload/pdf/ogs-61-95.pdf |
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