Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series
Thymic tumours are rare thoracic malignancies with thymic carcinoma accounting for approximately 12% of all thymic tumours compared to thymomas which account for approximately 86%. Unlike thymomas, it is very rare for thymic carcinomas to be associated with autoimmune disorders or paraneoplastic syn...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-02-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://www.karger.com/Article/FullText/529425 |
| _version_ | 1827981654123085824 |
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| author | Amy E. Smith Alisa Kane Francesca Watts Min Qiu Venessa Chin |
| author_facet | Amy E. Smith Alisa Kane Francesca Watts Min Qiu Venessa Chin |
| author_sort | Amy E. Smith |
| collection | DOAJ |
| description | Thymic tumours are rare thoracic malignancies with thymic carcinoma accounting for approximately 12% of all thymic tumours compared to thymomas which account for approximately 86%. Unlike thymomas, it is very rare for thymic carcinomas to be associated with autoimmune disorders or paraneoplastic syndromes. When these phenomena do occur, the vast majority are myasthenia gravis, pure red cell aplasia, or systemic lupus erythematous. Paraneoplastic Sjogren’s syndrome is a rare complication of thymic carcinoma, with only two cases previously reported. Here we present 2 cases of patients with metastatic thymic carcinoma who developed autoimmune phenomena consistent with Sjogren’s syndrome without classical symptoms prior to treatment. One patient opted for surveillance of their malignancy, while the other underwent chemoimmunotherapy with favourable results. These case reports describe two distinctive clinical presentations of a rare paraneoplastic phenomenon. |
| first_indexed | 2024-04-09T22:12:33Z |
| format | Article |
| id | doaj.art-2526f8df0060473dbb11f8179c9a5ed3 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-09T22:12:33Z |
| publishDate | 2023-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-2526f8df0060473dbb11f8179c9a5ed32023-03-23T06:54:58ZengKarger PublishersCase Reports in Oncology1662-65752023-02-0116111612310.1159/000529425529425Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case SeriesAmy E. Smith0https://orcid.org/0000-0002-0364-0703Alisa Kane1Francesca Watts2Min Qiu3Venessa Chin4https://orcid.org/0000-0002-4630-4451The Kinghorn Cancer Centre, St Vincent’s Hospital, Sydney, NSW, AustraliaDepartment of Immunology and HIV, St Vincent’s Hospital, Sydney, NSW, AustraliaDepartment of Anatomical Pathology, St Vincent’s Hospital, Sydney, NSW, AustraliaSchool of Medicine, University of Notre Dame Australia, Sydney, NSW, AustraliaThe Kinghorn Cancer Centre, St Vincent’s Hospital, Sydney, NSW, AustraliaThymic tumours are rare thoracic malignancies with thymic carcinoma accounting for approximately 12% of all thymic tumours compared to thymomas which account for approximately 86%. Unlike thymomas, it is very rare for thymic carcinomas to be associated with autoimmune disorders or paraneoplastic syndromes. When these phenomena do occur, the vast majority are myasthenia gravis, pure red cell aplasia, or systemic lupus erythematous. Paraneoplastic Sjogren’s syndrome is a rare complication of thymic carcinoma, with only two cases previously reported. Here we present 2 cases of patients with metastatic thymic carcinoma who developed autoimmune phenomena consistent with Sjogren’s syndrome without classical symptoms prior to treatment. One patient opted for surveillance of their malignancy, while the other underwent chemoimmunotherapy with favourable results. These case reports describe two distinctive clinical presentations of a rare paraneoplastic phenomenon.https://www.karger.com/Article/FullText/529425thymic carcinomaparaneoplastic syndromesjogren’s syndromeimmunotherapyautoimmune disorder |
| spellingShingle | Amy E. Smith Alisa Kane Francesca Watts Min Qiu Venessa Chin Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series Case Reports in Oncology thymic carcinoma paraneoplastic syndrome sjogren’s syndrome immunotherapy autoimmune disorder |
| title | Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series |
| title_full | Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series |
| title_fullStr | Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series |
| title_full_unstemmed | Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series |
| title_short | Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series |
| title_sort | two very rare cases of metastatic thymic carcinoma with sjogren s syndrome a case series |
| topic | thymic carcinoma paraneoplastic syndrome sjogren’s syndrome immunotherapy autoimmune disorder |
| url | https://www.karger.com/Article/FullText/529425 |
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