Opportunities and Challenges of RNA Interference Therapeutics in Oncology
As the discovery of RNA interference (RNAi) and the gradual conquering of a series of technical issues, a few of RNAi therapeutics have been approved in the non-tumor field abroad. With the advantages of high specificity, long duration of efficacy, and high success rate of development, RNAi therapeu...
| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2022-07-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.20 |
| _version_ | 1818161825167966208 |
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| author | Rui CHEN Yan XU |
| author_facet | Rui CHEN Yan XU |
| author_sort | Rui CHEN |
| collection | DOAJ |
| description | As the discovery of RNA interference (RNAi) and the gradual conquering of a series of technical issues, a few of RNAi therapeutics have been approved in the non-tumor field abroad. With the advantages of high specificity, long duration of efficacy, and high success rate of development, RNAi therapeutics have become the emerging field globally. There are no RNAi therapeutics approved in oncology so far, and people are hoping a breakthrough in the field. In the present article, the characteristics and potential anti-tumor mechanism of RNAi therapeutics, difficulties in delivery system and progress in oncology are described, and the potential reasons why their success in non-tumor field is difficult to be simply replicated in tumor field are analyzed, providing reference for research and clinical transformation of RNAi therapeutics in oncology. |
| first_indexed | 2024-12-11T16:23:55Z |
| format | Article |
| id | doaj.art-2529c317c943486d868b9fe3781d6f16 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-11T16:23:55Z |
| publishDate | 2022-07-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-2529c317c943486d868b9fe3781d6f162022-12-22T00:58:46ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872022-07-0125748248610.3779/j.issn.1009-3419.2022.102.20Opportunities and Challenges of RNA Interference Therapeutics in OncologyRui CHEN0Yan XU1Clinical Pharmacology Research Center,
Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, ChinaDepartment of Respiratory and Critical Care Medicine,
Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, ChinaAs the discovery of RNA interference (RNAi) and the gradual conquering of a series of technical issues, a few of RNAi therapeutics have been approved in the non-tumor field abroad. With the advantages of high specificity, long duration of efficacy, and high success rate of development, RNAi therapeutics have become the emerging field globally. There are no RNAi therapeutics approved in oncology so far, and people are hoping a breakthrough in the field. In the present article, the characteristics and potential anti-tumor mechanism of RNAi therapeutics, difficulties in delivery system and progress in oncology are described, and the potential reasons why their success in non-tumor field is difficult to be simply replicated in tumor field are analyzed, providing reference for research and clinical transformation of RNAi therapeutics in oncology.http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.20rna interferenceoncologydelivery systems |
| spellingShingle | Rui CHEN Yan XU Opportunities and Challenges of RNA Interference Therapeutics in Oncology Chinese Journal of Lung Cancer rna interference oncology delivery systems |
| title | Opportunities and Challenges of RNA Interference Therapeutics in Oncology |
| title_full | Opportunities and Challenges of RNA Interference Therapeutics in Oncology |
| title_fullStr | Opportunities and Challenges of RNA Interference Therapeutics in Oncology |
| title_full_unstemmed | Opportunities and Challenges of RNA Interference Therapeutics in Oncology |
| title_short | Opportunities and Challenges of RNA Interference Therapeutics in Oncology |
| title_sort | opportunities and challenges of rna interference therapeutics in oncology |
| topic | rna interference oncology delivery systems |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.20 |
| work_keys_str_mv | AT ruichen opportunitiesandchallengesofrnainterferencetherapeuticsinoncology AT yanxu opportunitiesandchallengesofrnainterferencetherapeuticsinoncology |