Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity
Alzheimer’s disease (AD), as a neurodegenerative disorder, is characterized by mass neuronal and synaptic loss and, currently, there are no successful curative therapies. Extracellular vesicles (EVs) are an emerging approach to intercellular communication via transferring cellular materials such as...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/11/10/796 |
| _version_ | 1797513876900675584 |
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| author | Yi-An Chen Cheng-Hsiu Lu Chien-Chih Ke Ren-Shyan Liu |
| author_facet | Yi-An Chen Cheng-Hsiu Lu Chien-Chih Ke Ren-Shyan Liu |
| author_sort | Yi-An Chen |
| collection | DOAJ |
| description | Alzheimer’s disease (AD), as a neurodegenerative disorder, is characterized by mass neuronal and synaptic loss and, currently, there are no successful curative therapies. Extracellular vesicles (EVs) are an emerging approach to intercellular communication via transferring cellular materials such as proteins, lipids, mRNAs, and miRNAs from parental cells to recipient cells, leading to the reprogramming of the molecular machinery. Numerous studies have suggested the therapeutic potential of EVs derived from mesenchymal stem cells (MSCs) in the treatment of AD, based on the neuroprotective, regenerative and immunomodulatory effects as effective as MSCs. In this review, we focus on the biology and function of EVs, the potential of MSC-derived EVs for AD therapy in preclinical and clinical studies, as well as the potent mechanisms of MSC-derived EVs actions. Finally, we highlight the modification strategies and diagnosis utilities in order to make advance in this field. |
| first_indexed | 2024-03-10T06:23:44Z |
| format | Article |
| id | doaj.art-2529f5c84d0d4dfdaba2a3636b4e2f92 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T06:23:44Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-2529f5c84d0d4dfdaba2a3636b4e2f922023-11-22T19:06:46ZengMDPI AGMembranes2077-03752021-10-01111079610.3390/membranes11100796Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and OpportunityYi-An Chen0Cheng-Hsiu Lu1Chien-Chih Ke2Ren-Shyan Liu3Department of Nuclear Medicine, Cheng Hsin General Hospital, Taipei 112, TaiwanCore Laboratory for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Nuclear Medicine, Cheng Hsin General Hospital, Taipei 112, TaiwanAlzheimer’s disease (AD), as a neurodegenerative disorder, is characterized by mass neuronal and synaptic loss and, currently, there are no successful curative therapies. Extracellular vesicles (EVs) are an emerging approach to intercellular communication via transferring cellular materials such as proteins, lipids, mRNAs, and miRNAs from parental cells to recipient cells, leading to the reprogramming of the molecular machinery. Numerous studies have suggested the therapeutic potential of EVs derived from mesenchymal stem cells (MSCs) in the treatment of AD, based on the neuroprotective, regenerative and immunomodulatory effects as effective as MSCs. In this review, we focus on the biology and function of EVs, the potential of MSC-derived EVs for AD therapy in preclinical and clinical studies, as well as the potent mechanisms of MSC-derived EVs actions. Finally, we highlight the modification strategies and diagnosis utilities in order to make advance in this field.https://www.mdpi.com/2077-0375/11/10/796Alzheimer’s diseasemesenchymal stem cellsextracellular vesiclestherapy |
| spellingShingle | Yi-An Chen Cheng-Hsiu Lu Chien-Chih Ke Ren-Shyan Liu Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity Membranes Alzheimer’s disease mesenchymal stem cells extracellular vesicles therapy |
| title | Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity |
| title_full | Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity |
| title_fullStr | Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity |
| title_short | Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer’s Disease: Progress and Opportunity |
| title_sort | mesenchymal stem cell derived extracellular vesicle based therapy for alzheimer s disease progress and opportunity |
| topic | Alzheimer’s disease mesenchymal stem cells extracellular vesicles therapy |
| url | https://www.mdpi.com/2077-0375/11/10/796 |
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