Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.

Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.

Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes. Imeglimin, a novel first-in-class small molecule tetrahydrotriazine drug candidate, improves glycemia and GSIS in preclinic...

Full description

Bibliographic Details
Main Authors:	Sophie Hallakou-Bozec, Micheline Kergoat, Pascale Fouqueray, Sébastien Bolze, David E Moller
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2021-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0241651

Similar Items

Imeglimin preserves islet β‐cell mass in Type 2 diabetic ZDF rats
by: Sophie Hallakou‐Bozec, et al.
Published: (2021-04-01)

Phase 2 trial with imeglimin in patients with Type 2 diabetes indicates effects on insulin secretion and sensitivity
by: Pierre Theurey, et al.
Published: (2022-11-01)

The mechanism by which imeglimin inhibits gluconeogenesis in rat liver cells
by: Guillaume Vial, et al.
Published: (2021-04-01)

Short‐and long‐term administration of imeglimin counters cardiorenal dysfunction in a rat model of metabolic syndrome
by: Marianne Lachaux, et al.
Published: (2020-07-01)

Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity
by: Vincent Jacques, et al.
Published: (2021-08-01)

Effects of Caffeine and Acetylcholine on Glucose-Stimulated Insulin Release from Islet Transplants in Mice
by: Chun-Liang Shi
Published: (1997-01-01)

Glucose-Lowering Effects of Imeglimin and Its Possible Beneficial Effects on Diabetic Complications
by: Hidekatsu Yanai, et al.
Published: (2023-05-01)

Imeglimin population pharmacokinetics and dose adjustment predictions for renal impairment in Japanese and Western patients with type 2 diabetes
by: Yoshiko Tomita, et al.
Published: (2022-04-01)

Stimulatory effect of imeglimin on incretin secretion
by: Quan Yingyue, et al.
Published: (2023-06-01)

Heterogenous glucose-stimulated insulin secretion at single islet level
by: Jiaxiang Yin, et al.
Published: (2023-12-01)

A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway
by: Shunsuke Funazaki, et al.
Published: (2022-01-01)

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets
by: Yi Cheng, et al.
Published: (2023-11-01)

Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules
by: Junpei Sanada, et al.
Published: (2022-08-01)

Imeglimin‐mediated glycemic control in maternally inherited deafness and diabetes
by: Ryoichi Ishibashi, et al.
Published: (2023-12-01)

Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets
by: Geetali Pradhan, et al.
Published: (2022-03-01)

Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets
by: Muhan Jing, et al.
Published: (2021-11-01)

The Possible Mechanisms by which Borapetol B Stimulates Insulin Release from Rat Islets
by: Ezarul Faradianna, Lokman, et al.
Published: (2014)

Methylamine Activates Glucose Uptake in Human Adipocytes Without Overpassing Action of Insulin or Stimulating its Secretion in Pancreatic Islets
by: Christian Carpéné, et al.
Published: (2019-08-01)

Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes
by: Kaori Hozumi, et al.
Published: (2023-01-01)

Islets secretory capacity determines glucose homoeostasis in the face of insulin resistance
by: P Wiesli, et al.
Published: (2004-09-01)

Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.
by: Craig S Nunemaker, et al.
Published: (2009-12-01)

Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice
by: Kyota Aoyagi, et al.
Published: (2024-03-01)

Development of Imeglimin Electrospun Nanofibers as a Potential Buccal Antidiabetic Therapeutic Approach
by: Ali A. Alamer, et al.
Published: (2023-04-01)

Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis
by: Pascale Gluais‐Dagorn, et al.
Published: (2022-01-01)

Imeglimin Exhibits Novel Anti-Inflammatory Effects on High-Glucose-Stimulated Mouse Microglia through ULK1-Mediated Suppression of the TXNIP–NLRP3 Axis
by: Hisashi Kato, et al.
Published: (2024-02-01)

Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+.
by: Rorsman, P, et al.
Published: (1985)

A Study of the Effects of Electromagnetic Field on Islets of Langerhans and Insulin Release in Rats
by: Khaki Amir Afshin, et al.
Published: (2015-01-01)

Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice
by: Head W Steven, et al.
Published: (2005-12-01)

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors.
by: Paola Llanos, et al.
Published: (2015-01-01)

The DPP-IV inhibitor, sitgliptin enhances glucose-stimulated insulin secretion from mouse isolated islets
by: Clark, A, et al.
Published: (2013)

Protocol for in vivo and ex vivo assessments of glucose-stimulated insulin secretion in mouse islet β cells
by: Yun-Xia Zhu, et al.
Published: (2021-09-01)

Protective effects of imeglimin on the development of atherosclerosis in ApoE KO mice treated with STZ
by: Junpei Sanada, et al.
Published: (2024-03-01)

Imeglimin prevents visceral hypersensitivity and colonic hyperpermeability in irritable bowel syndrome rat model
by: Tsukasa Nozu, et al.
Published: (2023-09-01)

Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/ insulin release from mouse pancreatic islets
by: INÊS E BALDEIRAS, et al.
Published: (2006-01-01)

Two Distinct Mechanisms Mediate the Involvement of Bone Marrow Cells in Islet Remodeling: Neogenesis of Insulin-Producing Cells and Support of Islet Recovery
by: Svetlana Iskovich, et al.
Published: (2015-05-01)

Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization.
by: Boah Lee, et al.
Published: (2017-01-01)

Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets.
by: Javier Pizarro-Delgado, et al.
Published: (2016-01-01)

Effect of Ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets
by: Reza Shafiee-Nick, et al.
Published: (2012-09-01)

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
by: Daniela Nasteska, et al.
Published: (2021-01-01)

Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes.
by: Fuhlendorff, J, et al.
Published: (1998)